Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4599165..4600741 Replicon chromosome
Accession NZ_CP060726
Organism Providencia rettgeri strain YPR25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H9X60_RS21280 Protein ID WP_172767528.1
Coordinates 4599165..4600484 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H9X60_RS21285 Protein ID WP_036959176.1
Coordinates 4600484..4600741 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X60_RS21270 4595102..4598149 - 3048 WP_172767527.1 formate dehydrogenase-N subunit alpha -
H9X60_RS21275 4598324..4599154 + 831 WP_036959175.1 formate dehydrogenase accessory sulfurtransferase FdhD -
H9X60_RS21280 4599165..4600484 - 1320 WP_172767528.1 type II toxin-antitoxin system HipA family toxin Toxin
H9X60_RS21285 4600484..4600741 - 258 WP_036959176.1 helix-turn-helix domain-containing protein Antitoxin
H9X60_RS21290 4601071..4602435 - 1365 WP_136134574.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
H9X60_RS21295 4602537..4604186 - 1650 WP_004906225.1 membrane protein insertase YidC -
H9X60_RS21300 4604189..4604449 - 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
H9X60_RS21305 4604413..4604772 - 360 WP_004906229.1 ribonuclease P protein component -
H9X60_RS21310 4604794..4604937 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50006.05 Da        Isoelectric Point: 6.6933

>T170871 WP_172767528.1 NZ_CP060726:c4600484-4599165 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKVNAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPRSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTKGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVLKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

>T170871 NZ_CP077760:c1766397-1766110 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.85 Da        Isoelectric Point: 9.6898

>AT170871 WP_036959176.1 NZ_CP060726:c4600741-4600484 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp

>AT170871 NZ_CP077760:c1766123-1765821 [Salmonella enterica subsp. enterica serovar Gallinarum]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References