Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4501160..4501743 Replicon chromosome
Accession NZ_CP060726
Organism Providencia rettgeri strain YPR25

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H9X60_RS20830 Protein ID WP_096863599.1
Coordinates 4501441..4501743 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H9X60_RS20825 Protein ID WP_004265229.1
Coordinates 4501160..4501444 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X60_RS20800 4496320..4497297 - 978 WP_004265237.1 6-phosphofructokinase -
H9X60_RS20805 4497704..4498648 - 945 WP_004265235.1 phosphatidate cytidylyltransferase -
H9X60_RS20810 4498645..4499286 - 642 WP_094961883.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
H9X60_RS20815 4499524..4500276 - 753 WP_004265231.1 M48 family metallopeptidase -
H9X60_RS20820 4500496..4501077 - 582 WP_172767500.1 HutD family protein -
H9X60_RS20825 4501160..4501444 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
H9X60_RS20830 4501441..4501743 - 303 WP_096863599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9X60_RS20835 4502000..4502572 - 573 WP_004265226.1 Spy/CpxP family protein refolding chaperone -
H9X60_RS20840 4502723..4503421 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
H9X60_RS20845 4503418..4504788 + 1371 WP_004265222.1 envelope stress sensor histidine kinase CpxA -
H9X60_RS20850 4505260..4506696 + 1437 WP_136135341.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11433.37 Da        Isoelectric Point: 10.0723

>T170870 WP_096863599.1 NZ_CP060726:c4501743-4501441 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T170870 NZ_CP077760:1362852-1362980 [Salmonella enterica subsp. enterica serovar Gallinarum]
GTGAAGATTTCGGACGGGTGTATTGTGCTAATGGCGGACGGTAACGAGGTGCAGGAGCTGCGCGAACAGCTTTATCAGGC
TAAACGGGTGGTTAAGGGGGGTGAAGGATGTGCTGGTTTAGTGGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT170870 WP_004265229.1 NZ_CP060726:c4501444-4501160 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT170870 NZ_CP077760:c1362930-1362579 [Salmonella enterica subsp. enterica serovar Gallinarum]
CCTGATAAAGCTGTTCGCGCAGCTCCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCTTCACC
GTCACGCCGCTCCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGC
AGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGTATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCC
GGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCTCTCCCCGGCCAG
TGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References