Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2501986..2502902 Replicon chromosome
Accession NZ_CP060726
Organism Providencia rettgeri strain YPR25

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag H9X60_RS11390 Protein ID WP_110591697.1
Coordinates 2502444..2502902 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag H9X60_RS11385 Protein ID WP_172767192.1
Coordinates 2501986..2502447 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X60_RS11355 2497652..2498266 + 615 WP_172767191.1 LysE family translocator -
H9X60_RS11360 2498290..2498763 - 474 WP_096863737.1 NUDIX domain-containing protein -
H9X60_RS11365 2499115..2499756 - 642 WP_096863735.1 leucine efflux protein LeuE -
H9X60_RS11370 2500230..2500931 + 702 WP_004254495.1 AzlC family ABC transporter permease -
H9X60_RS11375 2500928..2501242 + 315 WP_094960595.1 AzlD domain-containing protein -
H9X60_RS11380 2501430..2501897 + 468 WP_094960596.1 DUF1456 family protein -
H9X60_RS11385 2501986..2502447 + 462 WP_172767192.1 DUF2384 domain-containing protein Antitoxin
H9X60_RS11390 2502444..2502902 + 459 WP_110591697.1 RES domain-containing protein Toxin
H9X60_RS11395 2502903..2503793 - 891 WP_096863730.1 LysR family transcriptional regulator -
H9X60_RS11400 2503839..2504798 - 960 WP_172767193.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
H9X60_RS11405 2504904..2505326 - 423 WP_004254515.1 helix-turn-helix domain-containing protein -
H9X60_RS11410 2505357..2505920 - 564 WP_004254518.1 GNAT family N-acetyltransferase -
H9X60_RS11415 2505901..2507367 - 1467 WP_036957754.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-145)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17074.62 Da        Isoelectric Point: 6.2048

>T170866 WP_110591697.1 NZ_CP060726:2502444-2502902 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEVLVHINQDILLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Download         Length: 459 bp

>T170866 NZ_CP077757:2652523-2652885 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17104.59 Da        Isoelectric Point: 9.9140

>AT170866 WP_172767192.1 NZ_CP060726:2501986-2502447 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGIFS

Download         Length: 462 bp

>AT170866 NZ_CP077757:2652356-2652526 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References