Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1782777..1783425 Replicon chromosome
Accession NZ_CP060726
Organism Providencia rettgeri strain YPR25

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H9X60_RS07810 Protein ID WP_094961724.1
Coordinates 1783240..1783425 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H9X60_RS07805 Protein ID WP_164565692.1
Coordinates 1782777..1783190 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X60_RS07780 1778092..1779228 - 1137 WP_172766972.1 M4 family metallopeptidase -
H9X60_RS07785 1779387..1780304 - 918 WP_004264888.1 oxygen-dependent coproporphyrinogen oxidase -
H9X60_RS07790 1780441..1780872 + 432 WP_004264887.1 GNAT family acetyltransferase -
H9X60_RS07795 1780964..1781569 + 606 WP_050763802.1 RpoE-regulated lipoprotein -
H9X60_RS07800 1781812..1782711 + 900 WP_094961722.1 Dyp-type peroxidase -
H9X60_RS07805 1782777..1783190 - 414 WP_164565692.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H9X60_RS07810 1783240..1783425 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
H9X60_RS07815 1783748..1784770 + 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
H9X60_RS07820 1784770..1785600 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
H9X60_RS07825 1785600..1786460 + 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
H9X60_RS07830 1786463..1787551 + 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T170865 WP_094961724.1 NZ_CP060726:c1783425-1783240 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T170865 NZ_CP077757:2632936-2633145 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15372.33 Da        Isoelectric Point: 4.6719

>AT170865 WP_164565692.1 NZ_CP060726:c1783190-1782777 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDIDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAVAARKELKKTD

Download         Length: 414 bp

>AT170865 NZ_CP077757:2632631-2632924 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References