170864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1507392..1508049 Replicon chromosome
Accession NZ_CP060726
Organism Providencia rettgeri strain YPR25

Toxin (Protein)


Gene name cptA Uniprot ID A0A264VM08
Locus tag H9X60_RS06595 Protein ID WP_036958456.1
Coordinates 1507639..1508049 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4C097
Locus tag H9X60_RS06590 Protein ID WP_004261864.1
Coordinates 1507392..1507658 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X60_RS06575 1504388..1505284 - 897 WP_172766919.1 hypothetical protein -
H9X60_RS06580 1505529..1506149 - 621 WP_004261871.1 HD domain-containing protein -
H9X60_RS06585 1506161..1507144 - 984 WP_004261867.1 tRNA-modifying protein YgfZ -
H9X60_RS06590 1507392..1507658 + 267 WP_004261864.1 FAD assembly factor SdhE Antitoxin
H9X60_RS06595 1507639..1508049 + 411 WP_036958456.1 protein YgfX Toxin
H9X60_RS06600 1508149..1508667 - 519 WP_004261816.1 flavodoxin FldB -
H9X60_RS06605 1508785..1509687 + 903 WP_164564953.1 site-specific tyrosine recombinase XerD -
H9X60_RS06610 1509709..1510413 + 705 WP_096863312.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9X60_RS06615 1510423..1512156 + 1734 WP_004261807.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15568.53 Da        Isoelectric Point: 10.7733

>T170864 WP_036958456.1 NZ_CP060726:1507639-1508049 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T170864 NZ_CP077757:2318723-2318989 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10684.24 Da        Isoelectric Point: 4.8942

>AT170864 WP_004261864.1 NZ_CP060726:1507392-1507658 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT170864 NZ_CP077757:2318472-2318723 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A264VM08

Antitoxin

Source ID Structure
AlphaFold DB A0A345M2Q5

References