Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3675036..3675625 Replicon chromosome
Accession NZ_CP060725
Organism Sphingopyxis sp. OPL5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EEB18_RS17705 Protein ID WP_056350918.1
Coordinates 3675257..3675625 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EEB18_RS17700 Protein ID WP_187139758.1
Coordinates 3675036..3675260 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEB18_RS17670 3670097..3671041 - 945 WP_187139752.1 hypothetical protein -
EEB18_RS17675 3671010..3671714 - 705 WP_187139753.1 HAD-IA family hydrolase -
EEB18_RS17680 3671864..3673228 + 1365 WP_187139754.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
EEB18_RS17685 3673233..3673772 + 540 WP_187139755.1 GNAT family N-acetyltransferase -
EEB18_RS17690 3673769..3674083 + 315 WP_187139756.1 hypothetical protein -
EEB18_RS17695 3674106..3675005 + 900 WP_187139757.1 alpha/beta fold hydrolase -
EEB18_RS17700 3675036..3675260 + 225 WP_187139758.1 ribbon-helix-helix domain-containing protein Antitoxin
EEB18_RS17705 3675257..3675625 + 369 WP_056350918.1 PIN domain-containing protein Toxin
EEB18_RS17710 3675643..3677466 + 1824 WP_187139759.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
EEB18_RS17715 3677793..3677981 - 189 WP_187139760.1 hypothetical protein -
EEB18_RS17720 3678051..3678710 + 660 WP_187139761.1 HAD family phosphatase -
EEB18_RS17725 3678734..3679003 + 270 WP_187139762.1 hypothetical protein -
EEB18_RS17730 3679494..3680372 + 879 WP_187139763.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-38)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13072.23 Da        Isoelectric Point: 8.5316

>T170862 WP_056350918.1 NZ_CP060725:3675257-3675625 [Sphingopyxis sp. OPL5]
MIDAQFDSDILIDALNGVEAARSEIRRAGRKSVSRISWTEVMTAADPVSVKAVEAFLGCFAVEEVGDAVARRAAALRAER
KGLTLCDALVLATAQISGRILVTRNIKVFPAAMPGIRVPYTL

Download         Length: 369 bp

>T170862 NZ_CP077757:1098532-1098720 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8265.24 Da        Isoelectric Point: 6.3110

>AT170862 WP_187139758.1 NZ_CP060725:3675036-3675260 [Sphingopyxis sp. OPL5]
MRFLADIPDSDVEWLDSLAAGQGVSRAELVRRAVAAYRADASGDAIDNAFGIWRERADIGDGLKYQRRLRGKRE

Download         Length: 225 bp

>AT170862 NZ_CP077757:1098243-1098503 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References