Detailed information of TA system TA170861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE-PrpA/CC2985(antitoxin)
• Location: 2934102..2934642
• Replicon: chromosome
• Accession: NZ_CP060725
• Organism: Sphingopyxis sp. OPL5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EEB18_RS14085
• Protein ID: WP_187141178.1
• Coordinates: 2934102..2934398 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: EEB18_RS14090
• Protein ID: WP_187141179.1
• Coordinates: 2934391..2934642 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EEB18_RS14060	2929363..2930478	+	1116	WP_056345804.1	alanine dehydrogenase	-
EEB18_RS14065	2930500..2930748	+	249	WP_187141176.1	hypothetical protein	-
EEB18_RS14070	2931147..2931590	+	444	WP_187141177.1	succinate dehydrogenase, cytochrome b556 subunit	-
EEB18_RS14075	2931590..2931994	+	405	WP_056345814.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-
EEB18_RS14080	2931996..2933798	+	1803	WP_056345816.1	succinate dehydrogenase flavoprotein subunit	-
EEB18_RS14085	2934102..2934398	-	297	WP_187141178.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EEB18_RS14090	2934391..2934642	-	252	WP_187141179.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EEB18_RS14095	2934703..2934996	-	294	WP_056345822.1	hypothetical protein	-
EEB18_RS14100	2935098..2935307	-	210	WP_187141227.1	DUF167 domain-containing protein	-
EEB18_RS14105	2935373..2936368	-	996	WP_187141180.1	NADPH:quinone oxidoreductase family protein	-
EEB18_RS14110	2936390..2936980	-	591	WP_187141181.1	3-isopropylmalate dehydratase small subunit	-
EEB18_RS14115	2936977..2938407	-	1431	WP_187141182.1	3-isopropylmalate dehydratase large subunit	-
EEB18_RS14120	2938614..2939132	+	519	WP_187141183.1	beta-carotene hydroxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (5-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11512.02 Da
• Isoelectric Point: 6.3328

>T170861 WP_187141178.1 NZ_CP060725:c2934398-2934102 [Sphingopyxis sp. OPL5]
MRSIVVRPEAEVDIEDIADHTIAQWGADQARHYLGDLRRTIERLAVDGLRRPEEADVFPGLRRARSGHHFIFYLIDDERV
DVIRVLHERRDVMRQLQG

Nucleotide

• Length: 297 bp

>T170861 NZ_CP077757:56295-56447 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9217.34 Da
• Isoelectric Point: 4.8146

>AT170861 WP_187141179.1 NZ_CP060725:c2934642-2934391 [Sphingopyxis sp. OPL5]
MAAKNTSVALGEPFIEFARNKVESGEFATTSEVVREAMRRYIAYDDGVAALRREIQKGIDSGPARPFDWDAFMERKFGPA
SDA

Nucleotide

• Length: 252 bp

>AT170861 NZ_CP077757:55671-56270 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAATATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA