Detailed information of TA system TA170858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2536012..2536589
• Replicon: chromosome
• Accession: NZ_CP060719
• Organism: Thermomonas carbonis strain KCTC 42013

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9L16_RS11785
• Protein ID: WP_187551874.1
• Coordinates: 2536012..2536344 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H9L16_RS11790
• Protein ID: WP_187551875.1
• Coordinates: 2536332..2536589 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L16_RS11760	2531029..2531727	-	699	WP_187551869.1	hypothetical protein	-
H9L16_RS11765	2532220..2532474	+	255	WP_187551870.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H9L16_RS11770	2532474..2532881	+	408	WP_187551871.1	type II toxin-antitoxin system VapC family toxin	-
H9L16_RS11775	2534287..2534550	-	264	WP_187551872.1	hypothetical protein	-
H9L16_RS11780	2534815..2535990	+	1176	WP_187551873.1	IS481 family transposase	-
H9L16_RS11785	2536012..2536344	-	333	WP_187551874.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9L16_RS11790	2536332..2536589	-	258	WP_187551875.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H9L16_RS11795	2536741..2536953	-	213	WP_187551876.1	hypothetical protein	-
H9L16_RS11800	2537388..2537681	-	294	WP_187551877.1	HigA family addiction module antidote protein	-
H9L16_RS11805	2537681..2537959	-	279	WP_187551878.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H9L16_RS11810	2538456..2538665	-	210	WP_187551879.1	BrnA antitoxin family protein	-
H9L16_RS11815	2538674..2538952	-	279	WP_187551880.1	BrnT family toxin	-
H9L16_RS11820	2539094..2539537	-	444	WP_187551881.1	hypothetical protein	-
H9L16_RS11825	2540291..2540488	-	198	WP_187554169.1	DNA-binding protein	-
H9L16_RS11830	2540643..2540939	-	297	WP_187551882.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H9L16_RS11835	2540939..2541163	-	225	WP_187551883.1	addiction module protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2515226..2813752	298526
	-	inside	Integron	-	-	2526445..2629258	102813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12515.25 Da
• Isoelectric Point: 7.4235

>T170858 WP_187551874.1 NZ_CP060719:c2536344-2536012 [Thermomonas carbonis]
MAEIVWSEPALADLDAIADFIALENPVAAAELVKRVFGHVEQLVDHPDSGSRPQELARSRYRQIVEPPCRIFYRHDGHKV
FIVHVMRSERLLRKGQLTSRSRQVSDRGDG

Nucleotide

• Length: 333 bp

>T170858 NZ_CP077755:2355879-2356145 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9745.30 Da
• Isoelectric Point: 9.7317

>AT170858 WP_187551875.1 NZ_CP060719:c2536589-2536332 [Thermomonas carbonis]
MRTELVTTLKRQATELLSDIERDKEPILITQHGLPSAYLLDVETYQLMQQRMAILEGIARGEQAIAEGRTATHTQAKKRL
ARWLK

Nucleotide

• Length: 258 bp

>AT170858 NZ_CP077755:2355628-2355879 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA