Detailed information of TA system TA170853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 2659392..2661085
• Replicon: chromosome
• Accession: NZ_CP060714
• Organism: Diaphorobacter ruginosibacter strain DSM 27467

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: H9K76_RS11995
• Protein ID: WP_187595674.1
• Coordinates: 2660216..2661085 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: H9K76_RS11990
• Protein ID: WP_187595673.1
• Coordinates: 2659392..2660198 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9K76_RS11965	2654885..2655745	-	861	WP_187595668.1	IclR family transcriptional regulator	-
H9K76_RS11970	2655757..2656293	-	537	WP_187595669.1	cupin domain-containing protein	-
H9K76_RS11975	2656310..2657086	-	777	WP_187595670.1	SDR family oxidoreductase	-
H9K76_RS11980	2657476..2658465	-	990	WP_187595671.1	tripartite tricarboxylate transporter substrate binding protein	-
H9K76_RS11985	2658534..2659334	-	801	WP_187595672.1	aspartate dehydrogenase	-
H9K76_RS11990	2659392..2660198	-	807	WP_187595673.1	IclR family transcriptional regulator	Antitoxin
H9K76_RS11995	2660216..2661085	-	870	WP_187595674.1	alpha/beta hydrolase	Toxin
H9K76_RS12000	2661100..2661636	-	537	WP_187595675.1	cupin domain-containing protein	-
H9K76_RS12005	2661913..2663916	+	2004	WP_187595676.1	U32 family peptidase	-
H9K76_RS12010	2663927..2664613	+	687	WP_187595677.1	3'-5' exonuclease domain-containing protein 2	-
H9K76_RS12015	2664785..2666068	+	1284	WP_187595678.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (49-283)

Antitoxin

• Transcription regulator IclR, C-terminal (137-258)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30485.74 Da
• Isoelectric Point: 7.0029

>T170853 WP_187595674.1 NZ_CP060714:c2661085-2660216 [Diaphorobacter ruginosibacter]
MSSSSSSPGIQAAIERMEAVFPQRLVALGAQRQVAWREAGDGESDFAYVCLHGISSSAASWFGVAERLLANARVLAWDAP
GYGESTPLSVDAPTDADYARVLGESLAALGVRRCVLVGHSLGCLVAARWACDASALQIQIRQLVLMSPAGGYGAPAKAEQ
RARVMSGRVDALRDQGVSGIAAVIDQRLCAPGAPGPAREWVRWNASRMRAGGYLQAVHLLCSGDLGEASGRLTMPVHVWV
GTEDVVTTPEASEAWARRLGAQYVTLAKAGHACVVEQPEKIAQMLAHLS

Nucleotide

• Length: 870 bp

>T170853 NZ_CP077741:c2243442-2243233 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29238.25 Da
• Isoelectric Point: 6.2329

>AT170853 WP_187595673.1 NZ_CP060714:c2660198-2659392 [Diaphorobacter ruginosibacter]
MSDTTSSPDTDRDTDRYTVPALERGLRLMNCFSPTQPVWSAPDLARELELPRSTVFRMLTTLENMGYLQRSGTEYRLGLA
VLRLGYDYLSSQPLANLAQPVMQALHEQLGFTCNLALLDGTSIVYVARVGHSSEFQSAVRVGSRLPAHATVLGRVLLQDM
TAPQLRKLYGGNELPMFTPSTPRTVDDLLALIAQDVERGYAEGEGFYESGVSGIAAPVRGGDGKIVAGIGMVVPFAEVGR
ARSGHWVDQVVHATRELSGYLRAQHPMS

Nucleotide

• Length: 807 bp

>AT170853 NZ_CP077741:c2243747-2243454 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA