Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2659392..2661085 Replicon chromosome
Accession NZ_CP060714
Organism Diaphorobacter ruginosibacter strain DSM 27467

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H9K76_RS11995 Protein ID WP_187595674.1
Coordinates 2660216..2661085 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H9K76_RS11990 Protein ID WP_187595673.1
Coordinates 2659392..2660198 (-) Length 269 a.a.

Genomic Context

H9K76_RS12005H9K76_RS12010H9K76_RS12015H9K76_RS11965H9K76_RS11970H9K76_RS11975H9K76_RS11980H9K76_RS11985H9K76_RS11990H9K76_RS11995H9K76_RS12000
Location: 2661913..2663916 (2004 bp)
Type: Others
Protein ID: WP_187595676.1
Location: 2663927..2664613 (687 bp)
Type: Others
Protein ID: WP_187595677.1
Location: 2664785..2666068 (1284 bp)
Type: Others
Protein ID: WP_187595678.1
Location: 2654885..2655745 (861 bp)
Type: Others
Protein ID: WP_187595668.1
Location: 2655757..2656293 (537 bp)
Type: Others
Protein ID: WP_187595669.1
Location: 2656310..2657086 (777 bp)
Type: Others
Protein ID: WP_187595670.1
Location: 2657476..2658465 (990 bp)
Type: Others
Protein ID: WP_187595671.1
Location: 2658534..2659334 (801 bp)
Type: Others
Protein ID: WP_187595672.1
Location: 2659392..2660198 (807 bp)
Type: Antitoxin
Protein ID: WP_187595673.1
Location: 2660216..2661085 (870 bp)
Type: Toxin
Protein ID: WP_187595674.1
Location: 2661100..2661636 (537 bp)
Type: Others
Protein ID: WP_187595675.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9K76_RS119652654885..2655745-861WP_187595668.1IclR family transcriptional regulator-
H9K76_RS119702655757..2656293-537WP_187595669.1cupin domain-containing protein-
H9K76_RS119752656310..2657086-777WP_187595670.1SDR family oxidoreductase-
H9K76_RS119802657476..2658465-990WP_187595671.1tripartite tricarboxylate transporter substrate binding protein-
H9K76_RS119852658534..2659334-801WP_187595672.1aspartate dehydrogenase-
H9K76_RS119902659392..2660198-807WP_187595673.1IclR family transcriptional regulatorAntitoxin
H9K76_RS119952660216..2661085-870WP_187595674.1alpha/beta hydrolaseToxin
H9K76_RS120002661100..2661636-537WP_187595675.1cupin domain-containing protein-
H9K76_RS120052661913..2663916+2004WP_187595676.1U32 family peptidase-
H9K76_RS120102663927..2664613+687WP_187595677.13'-5' exonuclease domain-containing protein 2-
H9K76_RS120152664785..2666068+1284WP_187595678.1aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-283)

Antitoxin

Transcription regulator IclR, C-terminal

(137-258)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30485.74 Da        Isoelectric Point: 7.0029

>T170853 WP_187595674.1 NZ_CP060714:c2661085-2660216 [Diaphorobacter ruginosibacter]
MSSSSSSPGIQAAIERMEAVFPQRLVALGAQRQVAWREAGDGESDFAYVCLHGISSSAASWFGVAERLLANARVLAWDAP
GYGESTPLSVDAPTDADYARVLGESLAALGVRRCVLVGHSLGCLVAARWACDASALQIQIRQLVLMSPAGGYGAPAKAEQ
RARVMSGRVDALRDQGVSGIAAVIDQRLCAPGAPGPAREWVRWNASRMRAGGYLQAVHLLCSGDLGEASGRLTMPVHVWV
GTEDVVTTPEASEAWARRLGAQYVTLAKAGHACVVEQPEKIAQMLAHLS

Download         Length: 870 bp

>T170853 NZ_CP077741:c2243442-2243233 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29238.25 Da        Isoelectric Point: 6.2329

>AT170853 WP_187595673.1 NZ_CP060714:c2660198-2659392 [Diaphorobacter ruginosibacter]
MSDTTSSPDTDRDTDRYTVPALERGLRLMNCFSPTQPVWSAPDLARELELPRSTVFRMLTTLENMGYLQRSGTEYRLGLA
VLRLGYDYLSSQPLANLAQPVMQALHEQLGFTCNLALLDGTSIVYVARVGHSSEFQSAVRVGSRLPAHATVLGRVLLQDM
TAPQLRKLYGGNELPMFTPSTPRTVDDLLALIAQDVERGYAEGEGFYESGVSGIAAPVRGGDGKIVAGIGMVVPFAEVGR
ARSGHWVDQVVHATRELSGYLRAQHPMS

Download         Length: 807 bp

>AT170853 NZ_CP077741:c2243747-2243454 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References