Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2939248..2939870 Replicon chromosome
Accession NZ_CP060712
Organism Phycicoccus endophyticus strain JCM 31784

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H9L10_RS14150 Protein ID WP_166104131.1
Coordinates 2939460..2939870 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H9L10_RS14145 Protein ID WP_166104133.1
Coordinates 2939248..2939469 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L10_RS14130 2936397..2937257 + 861 WP_166104139.1 Fpg/Nei family DNA glycosylase -
H9L10_RS14135 2937372..2937758 + 387 WP_166104161.1 nitroreductase family deazaflavin-dependent oxidoreductase -
H9L10_RS14140 2937853..2939070 + 1218 WP_166104136.1 ATP-binding protein -
H9L10_RS14145 2939248..2939469 + 222 WP_166104133.1 antitoxin Antitoxin
H9L10_RS14150 2939460..2939870 + 411 WP_166104131.1 PIN domain nuclease Toxin
H9L10_RS14155 2939982..2940740 - 759 WP_166104128.1 class I SAM-dependent methyltransferase -
H9L10_RS14160 2941092..2941364 - 273 WP_166104125.1 hypothetical protein -
H9L10_RS14165 2941492..2942199 + 708 WP_166104122.1 aminoglycoside phosphotransferase family protein -
H9L10_RS14170 2942385..2942972 + 588 WP_166104159.1 ATP-binding protein -
H9L10_RS14175 2943091..2943288 + 198 WP_166104120.1 hypothetical protein -
H9L10_RS14180 2943272..2943610 + 339 WP_166104117.1 type II toxin-antitoxin system PemK/MazF family toxin -
H9L10_RS14185 2943787..2944353 + 567 WP_166104114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14685.81 Da        Isoelectric Point: 4.6059

>T170851 WP_166104131.1 NZ_CP060712:2939460-2939870 [Phycicoccus endophyticus]
VAVTEWLVDKSALVRLGDSPDAEDWAERIERGLVRIATVTRLEVGYSARSGHDARALFARPPLSAMPVEYLTPAIEDRAL
DVQLLLAAQGQHRAPSIPDLVIAAAAELAGLTVLHLDKDFDLIASITGQPVERLSL

Download         Length: 411 bp

>T170851 NZ_CP077741:c2056098-2055946 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7665.54 Da        Isoelectric Point: 4.2647

>AT170851 WP_166104133.1 NZ_CP060712:2939248-2939469 [Phycicoccus endophyticus]
VADVLIRDVPDAVLAGVDAHASRLGLSRVEYIRRRLAADAATSESTVSGSDLRAFADLAGDLDDPQVMGAAWQ

Download         Length: 222 bp

>AT170851 NZ_CP077741:c2056722-2056123 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References