Detailed information of TA system TA170844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4715159..4715973
• Replicon: chromosome
• Accession: NZ_CP060709
• Organism: Escherichia coli strain ST18

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: H9445_RS23020
• Protein ID: WP_001054376.1
• Coordinates: 4715716..4715973 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: H9445_RS23015
• Protein ID: WP_001309181.1
• Coordinates: 4715159..4715704 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9445_RS22990	4710850..4712163	-	1314	WP_000460842.1	galactitol-specific PTS transporter subunit IIC	-
H9445_RS22995	4712175..4712453	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H9445_RS23000	4712450..4713571	-	1122	WP_000010829.1	M42 family metallopeptidase	-
H9445_RS23005	4713970..4714188	-	219	Protein_4484	hypothetical protein	-
H9445_RS23010	4714357..4715103	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
H9445_RS23015	4715159..4715704	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
H9445_RS23020	4715716..4715973	-	258	WP_001054376.1	hypothetical protein	Toxin
H9445_RS23025	4716350..4716595	-	246	Protein_4488	GNAT family N-acetyltransferase	-
H9445_RS23030	4716965..4717951	+	987	WP_001323209.1	hypothetical protein	-
H9445_RS23035	4718534..4719514	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
H9445_RS23040	4719579..4720685	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimB / fimE	4670481..4725329	54848

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T170844 WP_001054376.1 NZ_CP060709:c4715973-4715716 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T170844 NZ_CP077738:c367599-367138 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT170844 WP_001309181.1 NZ_CP060709:c4715704-4715159 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT170844 NZ_CP077738:c367926-367612 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8