170834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2936364..2937031 Replicon chromosome
Accession NZ_CP060709
Organism Escherichia coli strain ST18

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag H9445_RS14585 Protein ID WP_001094400.1
Coordinates 2936702..2937031 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag H9445_RS14580 Protein ID WP_000072690.1
Coordinates 2936364..2936681 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9445_RS14550 2931416..2932425 - 1010 Protein_2851 arsenic transporter -
H9445_RS14555 2932567..2934270 + 1704 WP_000896263.1 hypothetical protein -
H9445_RS14560 2934842..2935065 + 224 Protein_2853 DUF905 family protein -
H9445_RS14565 2935168..2935626 + 459 WP_000211841.1 antirestriction protein -
H9445_RS14570 2935635..2936117 + 483 WP_001407480.1 RadC family protein -
H9445_RS14575 2936126..2936326 + 201 WP_001395452.1 DUF987 domain-containing protein -
H9445_RS14580 2936364..2936681 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9445_RS14585 2936702..2937031 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
H9445_RS14590 2937395..2941975 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T170834 WP_001094400.1 NZ_CP060709:2936702-2937031 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T170834 NZ_CP077715:c1555496-1555104 [Saccharolobus shibatae]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTATATTCGCTTTTAGATTACGTAGATAAGGTAGATGTTAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGCAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ACCCCATAACCCTTTCGAGACTTTTCTATAAATTAATGCGAAAATTTAACGTAGTAGAGGATCCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATGACGCATCTTATGCGTATGTTGCCGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAATGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT170834 WP_000072690.1 NZ_CP060709:2936364-2936681 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT170834 NZ_CP077715:c1555710-1555486 [Saccharolobus shibatae]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAGGCTTTAGAGGAAGCCATAAAGGAGAAGGAGAAGGAAGAACTTAAGAATACGGCTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAAGATGATTGGGTGAGGACTGTTAGGGAGAGTAGAGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References