Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2239356..2240187 Replicon chromosome
Accession NZ_CP060709
Organism Escherichia coli strain ST18

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H9445_RS11320 Protein ID WP_000854814.1
Coordinates 2239813..2240187 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag H9445_RS11315 Protein ID WP_001285584.1
Coordinates 2239356..2239724 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9445_RS11300 2237023..2238555 + 1533 WP_001350525.1 hypothetical protein -
H9445_RS11305 2238552..2238998 + 447 WP_000187523.1 RadC family protein -
H9445_RS11310 2239061..2239282 + 222 WP_000692323.1 DUF987 domain-containing protein -
H9445_RS11315 2239356..2239724 + 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H9445_RS11320 2239813..2240187 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
H9445_RS11325 2240184..2240378 + 195 WP_000988600.1 hypothetical protein -
H9445_RS11330 2240391..2240504 + 114 WP_001161660.1 DUF957 domain-containing protein -
H9445_RS11335 2240793..2240921 - 129 Protein_2222 transposase domain-containing protein -
H9445_RS11340 2240993..2241175 + 183 WP_001016348.1 hypothetical protein -
H9445_RS11345 2241276..2241605 - 330 WP_000450409.1 DUF496 family protein -
H9445_RS11350 2241777..2242835 - 1059 WP_001200891.1 FUSC family protein -
H9445_RS11355 2243033..2243506 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
H9445_RS11360 2243625..2244791 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T170831 WP_000854814.1 NZ_CP060709:2239813-2240187 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T170831 NZ_CP077713:1932418-1933032 [Saccharolobus shibatae]
ATGTTAAAATCACCGTTTGAAGTAACAATCTTGATTGAAGAGCACCCTTGTGAGGTTATGAGGATAATATCTAGTACTGG
GCTTAAAGCAACTGTTGACAACGTTAAACTCGGGGATAATGCAACTGATCACATAGTCCTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAACTTAAGTCCCATAGTACCAAAGTCTTAAAGCTTAATGATAGCAAAGTATGGGTTAGAACTAAT
GGATGCTCAGTTTGTAAGATTCTCTATACTTCAAATGTTGTCGTAGAGAAAATAAAAGTAGTAAAAGAGAGAACATTACT
CTATACACTTTTGGTCCCTAATACGATAGCTTTTAAGGAGTTTCTAGCTAATCTTACTAGTCAAGGGATAAAGTTTACAG
TCCTAAACACCTCTGAAATAAGCAGTAATGACTTAACTGATAGACAAATGGAAATATTGAAACTTGCATACAAGATGGGT
TATTTTGATGATGATAGGAGAGTAACTTTAACTGAATTAGCAAAGCAATTGGGAATATCAGCTCCGACTTTGGAGGAAAT
TATGAGGAGAGCGTTAAGGAAAGTCGTCAAGTATTATTTAGATAAAGTAGGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT170831 WP_001285584.1 NZ_CP060709:2239356-2239724 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT170831 NZ_CP077713:1932053-1932400 [Saccharolobus shibatae]
ATGATTAAGATAAAGAGGGTTTACGATCCAATAGAGAAAGATGACGGAATAAGAATCTTAGTGGATAGGTTATGGCCAAG
AGGAATTGGAAAAAATAAGGTAGATTTATGGCTTAAAGATATAGCACCTAGTGATGAGTTACGAAGATGGTACGGTCATG
ATGCCAGTAAATGGGATGAGTTCAAAAGGAAATATTTCGAGGAACTAGATGCTAATCCAAAGATGAGTATTTTATTGCAA
TTAATTAGAAAGGGCGAAAATATTACCTTACTTTACGCCTCAAAATCACCGTATAATAATGCAATTGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References