Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1807167..1807693 | Replicon | chromosome |
| Accession | NZ_CP060709 | ||
| Organism | Escherichia coli strain ST18 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | H9445_RS09105 | Protein ID | WP_000323025.1 |
| Coordinates | 1807167..1807454 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | H9445_RS09110 | Protein ID | WP_000534858.1 |
| Coordinates | 1807454..1807693 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9445_RS09060 | 1802191..1802406 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| H9445_RS09065 | 1803160..1803375 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| H9445_RS09070 | 1803676..1803888 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| H9445_RS09075 | 1803943..1804032 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| H9445_RS09080 | 1804310..1805062 | - | 753 | WP_001047135.1 | antitermination protein | - |
| H9445_RS09085 | 1805076..1806125 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| H9445_RS09090 | 1806127..1806405 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| H9445_RS09095 | 1806472..1806723 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| H9445_RS09100 | 1806940..1807095 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| H9445_RS09105 | 1807167..1807454 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| H9445_RS09110 | 1807454..1807693 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| H9445_RS09115 | 1807718..1808023 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| H9445_RS09120 | 1808226..1808558 | + | 333 | WP_001301033.1 | protein FlxA | - |
| H9445_RS09125 | 1808995..1809144 | - | 150 | WP_011443592.1 | hypothetical protein | - |
| H9445_RS09130 | 1809179..1809457 | - | 279 | Protein_1792 | hypothetical protein | - |
| H9445_RS09135 | 1809441..1809671 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| H9445_RS09140 | 1809755..1810162 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| H9445_RS09145 | 1810329..1810484 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| H9445_RS09150 | 1810644..1810862 | + | 219 | WP_001171942.1 | hypothetical protein | - |
| H9445_RS09155 | 1811430..1811618 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| H9445_RS09160 | 1811615..1811806 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
| H9445_RS09165 | 1811899..1812666 | + | 768 | Protein_1799 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1776625..1818565 | 41940 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T170822 WP_000323025.1 NZ_CP060709:c1807454-1807167 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T170822 NZ_CP077711:3569231-3569449 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT170822 WP_000534858.1 NZ_CP060709:c1807693-1807454 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT170822 NZ_CP077711:3568829-3569203 [Salmonella enterica subsp. enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|