Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1671107..1671745 Replicon chromosome
Accession NZ_CP060709
Organism Escherichia coli strain ST18

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H9445_RS08430 Protein ID WP_000813794.1
Coordinates 1671107..1671283 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H9445_RS08435 Protein ID WP_001270286.1
Coordinates 1671329..1671745 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9445_RS08410 1666726..1667940 - 1215 WP_001326689.1 BenE family transporter YdcO -
H9445_RS08415 1667993..1668529 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H9445_RS08420 1668602..1670563 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H9445_RS08425 1670655..1670885 - 231 WP_000494244.1 YncJ family protein -
H9445_RS08430 1671107..1671283 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H9445_RS08435 1671329..1671745 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H9445_RS08440 1671824..1673230 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
H9445_RS08445 1673475..1674620 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
H9445_RS08450 1674638..1675651 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
H9445_RS08455 1675652..1676593 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T170820 WP_000813794.1 NZ_CP060709:1671107-1671283 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T170820 NZ_CP077711:c2074545-2074315 [Salmonella enterica subsp. enterica]
ATGAAGGTGTATGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGATGGGCTTTTTGAGCTTCGGATTAAAGG
CAGCGATGGCATAGCTCGCGTTTTTTACTGCACCCTGGCAGGGAAGCGCATCGTCATGCTGCACAGCTTTATAAAGAAGA
CTCAGAAAACCCCTGTAGCTGAACGCAAAAAGGCAGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT170820 WP_001270286.1 NZ_CP060709:1671329-1671745 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT170820 NZ_CP077711:c2074325-2074017 [Salmonella enterica subsp. enterica]
ATGACTGGTAAACGTAATGCGCCAACTATAACGCACGATGAAATGGCCGCTAAATGGATGGAAGACCCAGCGTTCAAAGC
TGAATATGACGCCATTGCTGATGAGTTCGCGTTGCTTGACGAAATGCTGGCCGCACGTAAAGAAGCAGGTCTCACCCAGG
CTGAAGTTGCTGAACGGATGGGAACAAAAGCCACTGCTATAACCAGAATGGAAAGCAACCTTGCTGCTGGCGTCAGCGGA
CCATCTTTTACTACGCTGAAAAAGTTCGCACAGGCAACCGGGAAAAAACTACAGATCCGCTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References