Detailed information of TA system TA170802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4578021..4578835
• Replicon: chromosome
• Accession: NZ_CP060708
• Organism: Escherichia coli strain MFDpir

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: H9446_RS22150
• Protein ID: WP_001054376.1
• Coordinates: 4578578..4578835 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: H9446_RS22145
• Protein ID: WP_001309181.1
• Coordinates: 4578021..4578566 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9446_RS22120	4573712..4575025	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
H9446_RS22125	4575037..4575315	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H9446_RS22130	4575312..4576433	-	1122	WP_000010829.1	M42 family metallopeptidase	-
H9446_RS22135	4576832..4577050	-	219	Protein_4305	hypothetical protein	-
H9446_RS22140	4577219..4577965	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
H9446_RS22145	4578021..4578566	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
H9446_RS22150	4578578..4578835	-	258	WP_001054376.1	hypothetical protein	Toxin
H9446_RS22155	4579212..4579457	-	246	Protein_4309	GNAT family N-acetyltransferase	-
H9446_RS22160	4579827..4580813	+	987	WP_001323209.1	hypothetical protein	-
H9446_RS22165	4581396..4582376	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
H9446_RS22170	4582441..4583547	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T170802 WP_001054376.1 NZ_CP060708:c4578835-4578578 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T170802 NZ_CP077706:4542189-4542500 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT170802 WP_001309181.1 NZ_CP060708:c4578566-4578021 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT170802 NZ_CP077706:4542497-4542943 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8