Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2762803..2763470 Replicon chromosome
Accession NZ_CP060708
Organism Escherichia coli strain MFDpir

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag H9446_RS13485 Protein ID WP_001094400.1
Coordinates 2763141..2763470 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag H9446_RS13480 Protein ID WP_000072690.1
Coordinates 2762803..2763120 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9446_RS13450 2757855..2758864 - 1010 Protein_2626 arsenic transporter -
H9446_RS13455 2759006..2760709 + 1704 WP_000896263.1 hypothetical protein -
H9446_RS13460 2761281..2761504 + 224 Protein_2628 DUF905 family protein -
H9446_RS13465 2761607..2762065 + 459 WP_000211841.1 antirestriction protein -
H9446_RS13470 2762074..2762556 + 483 WP_001407480.1 RadC family protein -
H9446_RS13475 2762565..2762765 + 201 WP_001395452.1 DUF987 domain-containing protein -
H9446_RS13480 2762803..2763120 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9446_RS13485 2763141..2763470 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
H9446_RS13490 2763834..2768414 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T170792 WP_001094400.1 NZ_CP060708:2763141-2763470 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T170792 NZ_CP077705:c60260-59955 [Salmonella enterica subsp. enterica]
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACACCCTGTTCGTGGATGTCCAGAGTGACATTATCGACAC
CCCCGGACGGCGGATGGTAATCCCGCTGGCCAGCGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCTGTGG
TACATATCGGGGATGAGAGCTGGCGTCTGATGACCACAGATATGGCCAGTGTGCCGGCCTCAGTCATCGGGGAAGAGGTG
GCCGATCTCAGTCACCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCTGGGGGATTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT170792 WP_000072690.1 NZ_CP060708:2762803-2763120 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT170792 NZ_CP077705:c60480-60262 [Salmonella enterica subsp. enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References