Detailed information of TA system TA170763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1641702..1642230
• Replicon: chromosome
• Accession: NZ_CP060707
• Organism: Campylobacter concisus strain P1CDO2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5IRL2
• Locus tag: CVT00_RS08225
• Protein ID: WP_009295458.1
• Coordinates: 1641702..1641989 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5IPY6
• Locus tag: CVT00_RS08230
• Protein ID: WP_009295321.1
• Coordinates: 1641979..1642230 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT00_RS08200	1636855..1637518	+	664	Protein_1593	replisome organizer	-
CVT00_RS08205	1637625..1638462	+	838	Protein_1594	ATP-binding protein	-
CVT00_RS08210	1638525..1638698	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVT00_RS08215	1639366..1640958	-	1593	WP_009295460.1	relaxase/mobilization nuclease domain-containing protein	-
CVT00_RS08220	1640994..1641335	-	342	WP_107914740.1	hypothetical protein	-
CVT00_RS08225	1641702..1641989	-	288	WP_009295458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT00_RS08230	1641979..1642230	-	252	WP_009295321.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT00_RS08235	1642313..1644094	-	1782	WP_107914742.1	site-specific integrase	-
CVT00_RS08240	1645043..1645375	+	333	WP_103558904.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11299.19 Da
• Isoelectric Point: 9.7349

>T170763 WP_009295458.1 NZ_CP060707:c1641989-1641702 [Campylobacter concisus]
MSYELEFLPGALKEWQKLDNSIKVQFKKKLSERLENPKVAKDKLRGYEDVYKIKLRDVGYRLAYQVKDSEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T170763 NZ_CP077699:3563920-3564138 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8938.26 Da
• Isoelectric Point: 4.9901

>AT170763 WP_009295321.1 NZ_CP060707:c1642230-1641979 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSAVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT170763 NZ_CP077699:3563518-3563892 [Salmonella enterica subsp. enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: M5IRL2

Antitoxin

• AlphaFold DB: M5IPY6