Detailed information of TA system TA170762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1628485..1629013
• Replicon: chromosome
• Accession: NZ_CP060705
• Organism: Campylobacter concisus strain P13UCO-S1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5IRL2
• Locus tag: CVT08_RS08205
• Protein ID: WP_009295458.1
• Coordinates: 1628485..1628772 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5IPY6
• Locus tag: CVT08_RS08210
• Protein ID: WP_009295321.1
• Coordinates: 1628762..1629013 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT08_RS08180	1623638..1624301	+	664	Protein_1588	replisome organizer	-
CVT08_RS08185	1624409..1625246	+	838	Protein_1589	ATP-binding protein	-
CVT08_RS08190	1625308..1625481	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVT08_RS08195	1626149..1627741	-	1593	WP_009295460.1	relaxase/mobilization nuclease domain-containing protein	-
CVT08_RS08200	1627777..1628118	-	342	WP_009295459.1	hypothetical protein	-
CVT08_RS08205	1628485..1628772	-	288	WP_009295458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT08_RS08210	1628762..1629013	-	252	WP_009295321.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT08_RS08215	1629096..1630868	-	1773	WP_034964515.1	site-specific integrase	-
CVT08_RS08220	1631528..1632166	+	639	WP_107855822.1	hypothetical protein	-
CVT08_RS08225	1632166..1632543	+	378	WP_107855821.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11299.19 Da
• Isoelectric Point: 9.7349

>T170762 WP_009295458.1 NZ_CP060705:c1628772-1628485 [Campylobacter concisus]
MSYELEFLPGALKEWQKLDNSIKVQFKKKLSERLENPKVAKDKLRGYEDVYKIKLRDVGYRLAYQVKDSEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T170762 NZ_CP077699:c2181636-2181454 [Salmonella enterica subsp. enterica]
TTGAAAAGCTCGGAGTTGATAAAACTACTGGAAAGCAAAGGGTGGACGCTGGAACGAATTAACGGTAGTCATCACCATTT
TTCGCACCCTGACTTTCCTGTGATTATTACGGTTCCTCATCCCAGGAAAGATATAAAACCCGGAACGCTTAACCAGATAC
TGAAAAAGGCAAAGCTAAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8938.26 Da
• Isoelectric Point: 4.9901

>AT170762 WP_009295321.1 NZ_CP060705:c1629013-1628762 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSAVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT170762 NZ_CP077699:c2181411-2180998 [Salmonella enterica subsp. enterica]
ATGTTGTATCCTGCTTTTATCGAAGTGGATAAAGACGGTAGCGCCAGCGGGTGGTTTCCCGATGTTCCCGGCTGTATTTT
CGCCGGCAGCACTATTGAGGAAACCTATGCCGACGCACGCAGCGCTATCTGTGCTCATTTTGAAGTGCTCTGTGATAAGG
GGTTTGATATTCCCTCTCCCCGCAGCATCGAGCAACATGTCGCCGCCGAACCAGACGATTACAGTAACGGACGCTGGTTG
TATGTGGACGTAAATATGGATCAGTTTGACGGGAGAGCTGAACGCATCAACGTCACTCTTCCCCATCGCCTGCTCGATCG
CATCGACGCCACGGTAAAACAGCATCCCGACTACGGTAGCCGGAGTGCATTTCTGGCAGCAGCTGCGCGTAATGAGTTAC
AGAAATCGCTTTAA

Structures

Toxin

• AlphaFold DB: M5IRL2

Antitoxin

• AlphaFold DB: M5IPY6