Detailed information of TA system TA170758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3560953..3561539
• Replicon: chromosome
• Accession: NZ_CP060704
• Organism: Chitinimonas koreensis strain R2A43-10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H9L41_RS14700
• Protein ID: WP_028444455.1
• Coordinates: 3560953..3561135 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H9L41_RS14705
• Protein ID: WP_028444456.1
• Coordinates: 3561147..3561539 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L41_RS14680 (H9L41_14680)	3556346..3557788	+	1443	WP_028444451.1	oxygen-independent coproporphyrinogen III oxidase	-
H9L41_RS14685 (H9L41_14685)	3557910..3559895	+	1986	WP_028444452.1	ribonucleoside triphosphate reductase	-
H9L41_RS14690 (H9L41_14690)	3559952..3560095	+	144	WP_265583798.1	anaerobic ribonucleoside-triphosphate reductase	-
H9L41_RS14695 (H9L41_14695)	3560055..3560807	+	753	WP_028444454.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
H9L41_RS14700 (H9L41_14700)	3560953..3561135	+	183	WP_028444455.1	type II toxin-antitoxin system HicA family toxin	Toxin
H9L41_RS14705 (H9L41_14705)	3561147..3561539	+	393	WP_028444456.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H9L41_RS14710 (H9L41_14710)	3561774..3562451	+	678	WP_028444457.1	Crp/Fnr family transcriptional regulator	-
H9L41_RS14715 (H9L41_14715)	3562532..3564148	+	1617	WP_028444458.1	PAS domain-containing methyl-accepting chemotaxis protein	-
H9L41_RS14720 (H9L41_14720)	3564244..3564567	+	324	WP_187523437.1	DUF2249 domain-containing protein	-
H9L41_RS14725 (H9L41_14725)	3564564..3565913	+	1350	WP_034605852.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-125)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6700.73 Da
• Isoelectric Point: 10.7918

>T170758 WP_028444455.1 NZ_CP060704:3560953-3561135 [Chitinimonas koreensis]
MDSKQIIKQLEADGWFLARVKGSHHQFKHPTKPGLVTVKHPDGDIPAGTLNSIRKQAGWK

Nucleotide

• Length: 183 bp

>T170758 NZ_CP077699:201635-202120 [Salmonella enterica subsp. enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACTTTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13991.71 Da
• Isoelectric Point: 4.5442

>AT170758 WP_028444456.1 NZ_CP060704:3561147-3561539 [Chitinimonas koreensis]
MRFPVVLHTDDGVRYGVTVPDLPGCFSAGDTFDEALDSVAEAIDLHLEGLVEEGSEVPVAGAIAEHRANPEYAAGVWAVV
EVDVTRFDGKAEKINITLPRRLLARIDEYARAHGSTRSGFLADAARAAMR

Nucleotide

• Length: 393 bp

>AT170758 NZ_CP077699:201360-201647 [Salmonella enterica subsp. enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA