Detailed information of TA system TA170756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 1393336..1393916
• Replicon: chromosome
• Accession: NZ_CP060704
• Organism: Chitinimonas koreensis strain R2A43-10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H9L41_RS05935
• Protein ID: WP_028447872.1
• Coordinates: 1393566..1393916 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H9L41_RS05930
• Protein ID: WP_028447873.1
• Coordinates: 1393336..1393569 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L41_RS05910 (H9L41_05910)	1388558..1389448	-	891	WP_028447877.1	LysR substrate-binding domain-containing protein	-
H9L41_RS05915 (H9L41_05915)	1389609..1390400	+	792	WP_028447876.1	transporter substrate-binding domain-containing protein	-
H9L41_RS05920 (H9L41_05920)	1390445..1391548	+	1104	WP_028447875.1	alanine racemase	-
H9L41_RS05925 (H9L41_05925)	1391624..1393339	+	1716	WP_028447874.1	glutamine--tRNA ligase/YqeY domain fusion protein	-
H9L41_RS05930 (H9L41_05930)	1393336..1393569	+	234	WP_028447873.1	DUF433 domain-containing protein	Antitoxin
H9L41_RS05935 (H9L41_05935)	1393566..1393916	+	351	WP_028447872.1	DUF5615 family PIN-like protein	Toxin
H9L41_RS05940 (H9L41_05940)	1393916..1394497	+	582	WP_034608076.1	HD domain-containing protein	-
H9L41_RS05945 (H9L41_05945)	1394545..1394784	+	240	WP_028447870.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H9L41_RS05950 (H9L41_05950)	1394784..1395164	+	381	WP_028447869.1	type II toxin-antitoxin system VapC family toxin	-
H9L41_RS05955 (H9L41_05955)	1395178..1396242	+	1065	WP_028447868.1	uroporphyrinogen decarboxylase	-
H9L41_RS05960 (H9L41_05960)	1396637..1398814	+	2178	WP_028447867.1	primosomal protein N'	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-78)

Antitoxin

• Protein of unknown function DUF433 (11-66)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12498.36 Da
• Isoelectric Point: 3.9696

>T170756 WP_028447872.1 NZ_CP060704:1393566-1393916 [Chitinimonas koreensis]
MILWLDAQLPPVLAAWLTETFGLSAYALRDLGLRDATDLEIFAEARQAGAILLSKDSDFADLVTRLGPPPQLLWLTCGNT
SNRSLCSLLSATLGEALSLLEQGMPIVEIDGRESSP

Nucleotide

• Length: 351 bp

>T170756 NZ_CP077697:88947-89375 [Salmonella enterica subsp. enterica]
ATGAAACAGCCGCGGACGAAGACGTATATGCTCGATACCAATATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAAAAGT
GCTGAAACGCCTCGAGCAGGCGGTGCTGCGCAATCACCGGATCGTAGTGTCGGCTATTACCTATGCGGAAATGCGCTTCG
GCGCGATCGGCAAAAAAGCCTCACCGCGCCACGCGCAGCTGGTAGACGCGTTCTGCGCGAGGCTCGATACCATTCTGCCG
TGGGATAAAGCCGCGGTGGATGCCACTACTGATATTAAAGCAGCACTGGCCGCCGCCGGCACGCCGATCGGCCCCAACGA
CACGGCGATTGCCGGACATGCCATTGCGGCCGGTGCCGTGCTGGTGACCAATAATACGCGGGAGTTTGAGCGGGTGCCGG
GTCTGAAGCTGGAAGACTGGGTCAAGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8465.90 Da
• Isoelectric Point: 4.9607

>AT170756 WP_028447873.1 NZ_CP060704:1393336-1393569 [Chitinimonas koreensis]
MSLDRTLMARITQRPGQCGGRPCVRGMRIRVADVLDMLANGMDTAEILMDYPDLEADDIRACLAFAASRLDIPRLAA

Nucleotide

• Length: 234 bp

>AT170756 NZ_CP077697:88720-88950 [Salmonella enterica subsp. enterica]
ATGAGAACCGTATCGATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGATGGCGTCAG
CGAGCTCGAAATCGTGCGCGAGGGCGACAGCATCATCCTGCGCCCGGTCCGCCCGACCTGGGAGTCGTTCTTCCGGGAAG
AAAAGGCCGACGCGGACTTTATGGCCGAGCGCGAGGATGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA