Detailed information of TA system TA170753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4420517..4421775
• Replicon: chromosome
• Accession: NZ_CP060703
• Organism: Pseudomonas aeruginosa strain NRD619

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H9W85_RS20385
• Protein ID: WP_012614407.1
• Coordinates: 4420517..4421272 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: H9W85_RS20390
• Protein ID: WP_003086329.1
• Coordinates: 4421407..4421775 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9W85_RS20375	4415690..4418233	+	2544	WP_021205057.1	acyl-homoserine-lactone acylase QuiP	-
H9W85_RS20380	4418388..4419749	-	1362	WP_134236573.1	DNA recombination protein RmuC	-
H9W85_RS20385	4420517..4421272	-	756	WP_012614407.1	RES family NAD+ phosphorylase	Toxin
H9W85_RS20390	4421407..4421775	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
H9W85_RS20395	4421848..4423134	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
H9W85_RS20400	4423190..4424779	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
H9W85_RS20405	4424858..4425334	+	477	WP_004353334.1	elongation factor GreAB	-
H9W85_RS20410	4425337..4425612	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T170753 WP_012614407.1 NZ_CP060703:c4421272-4420517 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T170753 NZ_CP077696:c4607093-4606782 [Salmonella enterica subsp. enterica]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT170753 WP_003086329.1 NZ_CP060703:c4421775-4421407 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT170753 NZ_CP077696:c4606781-4606491 [Salmonella enterica subsp. enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7