170752

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3496472..3497693 Replicon chromosome
Accession NZ_CP060703
Organism Pseudomonas aeruginosa strain NRD619

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H9W85_RS16070 Protein ID WP_003160088.1
Coordinates 3497115..3497693 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H9W85_RS16065 Protein ID WP_023085114.1
Coordinates 3496472..3497026 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9W85_RS16040 3492040..3492591 + 552 WP_003102727.1 XRE family transcriptional regulator -
H9W85_RS16045 3492588..3492986 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
H9W85_RS16050 3492999..3493322 - 324 WP_003162861.1 multidrug efflux SMR transporter -
H9W85_RS16055 3493653..3494114 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
H9W85_RS16060 3494119..3496314 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
H9W85_RS16065 3496472..3497026 + 555 WP_023085114.1 helix-turn-helix domain-containing protein Antitoxin
H9W85_RS16070 3497115..3497693 + 579 WP_003160088.1 HD domain-containing protein Toxin
H9W85_RS16075 3497802..3498989 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
H9W85_RS16080 3498979..3501150 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
H9W85_RS16085 3501140..3502417 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T170752 WP_003160088.1 NZ_CP060703:3497115-3497693 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T170752 NZ_CP077696:c4105325-4104912 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATGCTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGTTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT170752 WP_023085114.1 NZ_CP060703:3496472-3497026 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQSLARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT170752 NZ_CP077696:c4105572-4105306 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References