Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141803..142308 Replicon chromosome
Accession NZ_CP060703
Organism Pseudomonas aeruginosa strain NRD619

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag H9W85_RS00650 Protein ID WP_003083773.1
Coordinates 141803..142084 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag H9W85_RS00655 Protein ID WP_003083775.1
Coordinates 142081..142308 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9W85_RS00625 137054..138403 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
H9W85_RS00630 138452..139138 + 687 WP_003083762.1 FadR family transcriptional regulator -
H9W85_RS00635 139239..139973 + 735 WP_003083764.1 GntR family transcriptional regulator -
H9W85_RS00640 140177..140563 + 387 WP_003083767.1 aegerolysin family protein -
H9W85_RS00645 140595..141503 - 909 WP_003083769.1 LysR family transcriptional regulator -
H9W85_RS00650 141803..142084 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
H9W85_RS00655 142081..142308 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
H9W85_RS00660 142484..143104 - 621 WP_003101226.1 hypothetical protein -
H9W85_RS00665 143205..143705 + 501 WP_003101228.1 LEA type 2 family protein -
H9W85_RS00670 143778..144119 + 342 WP_003101229.1 alkylphosphonate utilization protein -
H9W85_RS00675 144201..145628 - 1428 WP_003083784.1 GABA permease -
H9W85_RS00680 145797..147290 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T170750 WP_003083773.1 NZ_CP060703:c142084-141803 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T170750 NZ_CP077696:2387982-2388266 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT170750 WP_003083775.1 NZ_CP060703:c142308-142081 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT170750 NZ_CP077696:2387744-2387992 [Salmonella enterica subsp. enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References