Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 141803..142308 | Replicon | chromosome |
Accession | NZ_CP060703 | ||
Organism | Pseudomonas aeruginosa strain NRD619 |
Toxin (Protein)
Gene name | parE | Uniprot ID | V6A7K8 |
Locus tag | H9W85_RS00650 | Protein ID | WP_003083773.1 |
Coordinates | 141803..142084 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1C7BDS9 |
Locus tag | H9W85_RS00655 | Protein ID | WP_003083775.1 |
Coordinates | 142081..142308 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H9W85_RS00625 | 137054..138403 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
H9W85_RS00630 | 138452..139138 | + | 687 | WP_003083762.1 | FadR family transcriptional regulator | - |
H9W85_RS00635 | 139239..139973 | + | 735 | WP_003083764.1 | GntR family transcriptional regulator | - |
H9W85_RS00640 | 140177..140563 | + | 387 | WP_003083767.1 | aegerolysin family protein | - |
H9W85_RS00645 | 140595..141503 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
H9W85_RS00650 | 141803..142084 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
H9W85_RS00655 | 142081..142308 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
H9W85_RS00660 | 142484..143104 | - | 621 | WP_003101226.1 | hypothetical protein | - |
H9W85_RS00665 | 143205..143705 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
H9W85_RS00670 | 143778..144119 | + | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
H9W85_RS00675 | 144201..145628 | - | 1428 | WP_003083784.1 | GABA permease | - |
H9W85_RS00680 | 145797..147290 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T170750 WP_003083773.1 NZ_CP060703:c142084-141803 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T170750 NZ_CP077696:2387982-2388266 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT170750 WP_003083775.1 NZ_CP060703:c142308-142081 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT170750 NZ_CP077696:2387744-2387992 [Salmonella enterica subsp. enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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