Detailed information of TA system TA170746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1922801..1923395
• Replicon: chromosome
• Accession: NZ_CP060701
• Organism: Ralstonia solanacearum strain FJAT454.F50-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G3A6N4
• Locus tag: H9X76_RS09225
• Protein ID: WP_016721901.1
• Coordinates: 1923132..1923395 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H9X76_RS09220
• Protein ID: WP_038961924.1
• Coordinates: 1922801..1923139 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9X76_RS09190	1919183..1919521	+	339	WP_016721894.1	phage tail protein	-
H9X76_RS09195	1919518..1920195	+	678	WP_016721895.1	phage tail protein	-
H9X76_RS09200	1920201..1920797	+	597	WP_016721896.1	tail fiber assembly protein	-
H9X76_RS09205	1920794..1921495	+	702	WP_071895496.1	phage minor tail protein L	-
H9X76_RS09210	1921497..1922207	+	711	WP_071895497.1	C40 family peptidase	-
H9X76_RS09215	1922211..1922804	+	594	WP_016721899.1	tail assembly protein	-
H9X76_RS09220	1922801..1923139	-	339	WP_038961924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H9X76_RS09225	1923132..1923395	-	264	WP_016721901.1	type II toxin-antitoxin system HicA family toxin	Toxin
H9X76_RS09230	1923448..1926603	+	3156	WP_187810758.1	host specificity protein J	-
H9X76_RS09235	1926940..1927596	+	657	WP_038961925.1	hypothetical protein	-
H9X76_RS09240	1927665..1928156	+	492	WP_038961926.1	glycoside hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1853374..1928156	74782

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.30 Da
• Isoelectric Point: 8.7458

>T170746 WP_016721901.1 NZ_CP060701:c1923395-1923132 [Ralstonia solanacearum]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Nucleotide

• Length: 264 bp

>T170746 NZ_CP077696:745163-745447 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCTGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12183.80 Da
• Isoelectric Point: 4.8946

>AT170746 WP_038961924.1 NZ_CP060701:c1923139-1922801 [Ralstonia solanacearum]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLRTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Nucleotide

• Length: 339 bp

>AT170746 NZ_CP077696:744931-745173 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAATGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: G3A6N4