Detailed information of TA system TA170742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1318066..1318587
• Replicon: chromosome
• Accession: NZ_CP060700
• Organism: Staphylococcus pseudintermedius strain cdc 18-1182

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: H9Q12_RS06440
• Protein ID: WP_110178839.1
• Coordinates: 1318066..1318287 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A166R1D0
• Locus tag: H9Q12_RS06445
• Protein ID: WP_014613363.1
• Coordinates: 1318300..1318587 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q12_RS06420	1313528..1314256	-	729	WP_014613368.1	hypothetical protein	-
H9Q12_RS06425	1315343..1315489	-	147	WP_014613367.1	hypothetical protein	-
H9Q12_RS06430	1315575..1317755	-	2181	WP_187470860.1	heavy metal translocating P-type ATPase	-
H9Q12_RS06435	1317856..1318062	-	207	WP_014613365.1	cation transporter	-
H9Q12_RS06440	1318066..1318287	-	222	WP_110178839.1	heavy-metal-associated domain-containing protein	Toxin
H9Q12_RS06445	1318300..1318587	-	288	WP_014613363.1	copper-sensing transcriptional repressor CsoR	Antitoxin
H9Q12_RS06450	1318719..1320209	+	1491	WP_063284938.1	cardiolipin synthase	-
H9Q12_RS06455	1320230..1320886	+	657	WP_014613361.1	HD domain-containing protein	-
H9Q12_RS06460	1320940..1321806	-	867	WP_014613360.1	membrane protein insertase YidC	-
H9Q12_RS06465	1321895..1322533	-	639	WP_063284943.1	thiamine phosphate synthase	-
H9Q12_RS06470	1322523..1323326	-	804	WP_014613358.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (21-64)

Antitoxin

• Metal-sensitive transcriptional repressor (3-93)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8081.10 Da
• Isoelectric Point: 4.3480

>T170742 WP_110178839.1 NZ_CP060700:c1318287-1318066 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGYPVIQSHKGV

Nucleotide

• Length: 222 bp

>T170742 NZ_CP077694:c118104-117688 [Salmonella enterica subsp. enterica]
GTGAACAAAACGTATATGCTGGATACCAATATCTGCTCATTCATCATGCGTGAGCAGCCGAAGGCCGTGATCAGACGCTT
AGAGCAAGCGGTGCTGCGCAACCATCGCATCGTGGTCTCCGCTATTACCTACGCCGAAATGCGCTTCGGTGCTATCGGGA
AAAAGGCCTCGCCCCGTCATGGCCAACTGGTCGATGCGTTCTGCGCCCGCCTCGATGCGATTCTGCCGTGGGACCGTGCC
GCAGTCGATGCCACTGTAGAGGTCAAAGCAGCACTAACCGCAGCCGGTACACCCATCGGTCCCAACGACACAGCGATTGC
CGGACATGCTATAGCTGCAGGGGCCATTCTGGTGACCAATAATACGCGAGAGTTTGAGCGGGTGCCAAATTTGGTATTAG
AAGACTGGGTTAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10997.59 Da
• Isoelectric Point: 7.0504

>AT170742 WP_014613363.1 NZ_CP060700:c1318587-1318300 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Nucleotide

• Length: 288 bp

>AT170742 NZ_CP077694:c118331-118101 [Salmonella enterica subsp. enterica]
ATGCGAACAGTATCTATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCTCGCGATTTGGATTTTGAAGGGGTGAG
TGAGTTGGAGATTGTCCGAGAAGGGGACAGCATCATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
AAAAGGCCGACGCAGACTTTTTGGTGGAGCGTGAAGACGTGGTCAGTGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A166R1D0