Detailed information of TA system TA170740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2605035..2605585
• Replicon: chromosome
• Accession: NZ_CP060698
• Organism: Amniculibacterium sp. G2-70

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H9Q20_RS12135
• Protein ID: WP_187477907.1
• Coordinates: 2605035..2605337 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: H9Q20_RS12140
• Protein ID: WP_124643243.1
• Coordinates: 2605334..2605585 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q20_RS12120	2601678..2602556	-	879	WP_187477904.1	hypothetical protein	-
H9Q20_RS12125	2602566..2603843	-	1278	WP_187477905.1	DNA (cytosine-5-)-methyltransferase	-
H9Q20_RS12130	2603840..2604142	-	303	WP_187477906.1	helix-turn-helix domain-containing protein	-
H9Q20_RS12135	2605035..2605337	-	303	WP_187477907.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9Q20_RS12140	2605334..2605585	-	252	WP_124643243.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H9Q20_RS12145	2605735..2606652	-	918	WP_124643358.1	hypothetical protein	-
H9Q20_RS12150	2607438..2608148	-	711	WP_187478618.1	DUF1275 domain-containing protein	-
H9Q20_RS12155	2608922..2609308	-	387	WP_187477908.1	hypothetical protein	-
H9Q20_RS12160	2609292..2609573	-	282	WP_187477909.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2584983..2657595	72612

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12171.75 Da
• Isoelectric Point: 5.7626

>T170740 WP_187477907.1 NZ_CP060698:c2605337-2605035 [Amniculibacterium sp. G2-70]
MNYKISVEAKNDIEKIWLYTFENWSLKQADRYFDLIMDEVEYIAENPNSGKDYSDVRKGYLRSRIKSHFIFYKVNKKQNE
VEIIRVLHQSMDIENRLNDE

Nucleotide

• Length: 303 bp

>T170740 NZ_CP077693:c4879711-4879400 [Salmonella enterica subsp. enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9759.14 Da
• Isoelectric Point: 9.9754

>AT170740 WP_124643243.1 NZ_CP060698:c2605585-2605334 [Amniculibacterium sp. G2-70]
MAKNTSILLGDYFDNFINQQIKSGKFTSASEVVRTALRMFEFEESKKTELINELKKGEKSGFVKEFNRENFRKELHQKHL
AEK

Nucleotide

• Length: 252 bp

>AT170740 NZ_CP077693:c4879399-4879109 [Salmonella enterica subsp. enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA