Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2103977..2104545 Replicon chromosome
Accession NZ_CP060693
Organism Aliarcobacter cryaerophilus strain 16CS1285-4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HOO34_RS11095 Protein ID WP_105924761.1
Coordinates 2103977..2104309 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HOO34_RS11100 Protein ID WP_105924762.1
Coordinates 2104303..2104545 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO34_RS11075 2099558..2101141 - 1584 WP_105909424.1 inorganic phosphate transporter -
HOO34_RS11080 2101334..2101864 - 531 WP_187474495.1 hypothetical protein -
HOO34_RS11085 2101812..2102600 + 789 WP_187475317.1 hypothetical protein -
HOO34_RS11090 2102671..2103987 + 1317 WP_187474496.1 aminotransferase class V-fold PLP-dependent enzyme -
HOO34_RS11095 2103977..2104309 - 333 WP_105924761.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HOO34_RS11100 2104303..2104545 - 243 WP_105924762.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HOO34_RS11105 2104703..2105845 + 1143 WP_187474497.1 metallophosphoesterase -
HOO34_RS11110 2105857..2106273 - 417 WP_066156012.1 Hsp20/alpha crystallin family protein -
HOO34_RS11115 2106376..2106819 - 444 WP_105909431.1 hemerythrin family protein -
HOO34_RS11120 2106886..2107932 - 1047 WP_105909432.1 sulfate ABC transporter ATP-binding protein -
HOO34_RS11125 2107948..2108808 - 861 WP_187474498.1 sulfate ABC transporter permease subunit CysW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12479.53 Da        Isoelectric Point: 9.5322

>T170736 WP_105924761.1 NZ_CP060693:c2104309-2103977 [Aliarcobacter cryaerophilus]
MVNYIPSKGDIVTLDFDPQKGHEQKGRRPALILSNKTFNKALGLAFACPITSTKRDFPFHVKIQSQKISGFIMAEQLKSI
DYDSRNIKFVEKVDKQILEEIEAIVDAIIK

Download         Length: 333 bp

>T170736 NZ_CP077693:3665368-3665586 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9011.34 Da        Isoelectric Point: 9.5169

>AT170736 WP_105924762.1 NZ_CP060693:c2104545-2104303 [Aliarcobacter cryaerophilus]
MTVTISKWGNSQGFRVPKDILDKLNLAVGDLVNISQKDNKLIIEPVKKEKKYSIDELVNNLPKGYKASEEFSSKSGSEIW

Download         Length: 243 bp

>AT170736 NZ_CP077693:3664966-3665340 [Salmonella enterica subsp. enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References