Detailed information of TA system TA170733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 385919..386489
• Replicon: chromosome
• Accession: NZ_CP060693
• Organism: Aliarcobacter cryaerophilus strain 16CS1285-4

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HOO34_RS01890
• Protein ID: WP_187474766.1
• Coordinates: 385919..386218 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HOO34_RS01895
• Protein ID: WP_187474767.1
• Coordinates: 386211..386489 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOO34_RS01870	380996..381193	-	198	WP_187474762.1	hypothetical protein	-
HOO34_RS01875	381535..384270	+	2736	WP_187474763.1	hypothetical protein	-
HOO34_RS01880	384741..385271	+	531	WP_187474764.1	Arm DNA-binding domain-containing protein	-
HOO34_RS01885	385391..385876	+	486	WP_187474765.1	site-specific integrase	-
HOO34_RS01890	385919..386218	+	300	WP_187474766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HOO34_RS01895	386211..386489	+	279	WP_187474767.1	putative addiction module antidote protein	Antitoxin
HOO34_RS01900	386779..387321	+	543	WP_187474768.1	inovirus-type Gp2 protein	-
HOO34_RS01905	387340..388350	+	1011	WP_187474769.1	IS1634 family transposase	-
HOO34_RS01910	388296..388874	+	579	WP_187475249.1	hypothetical protein	-
HOO34_RS01915	388971..389321	+	351	WP_187474770.1	hypothetical protein	-
HOO34_RS01920	389392..389607	+	216	WP_187474771.1	ribbon-helix-helix protein, CopG family	-
HOO34_RS01925	389597..389851	+	255	WP_187474772.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HOO34_RS01930	389928..390041	+	114	WP_108723439.1	DUF2958 domain-containing protein	-
HOO34_RS01935	390494..390799	+	306	WP_105915671.1	hypothetical protein	-
HOO34_RS01940	390847..391383	+	537	WP_187474773.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-94)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11500.38 Da
• Isoelectric Point: 9.6104

>T170733 WP_187474766.1 NZ_CP060693:385919-386218 [Aliarcobacter cryaerophilus]
MYLIKQTELFSKWLYKLKDIQGKVSILRRVDRMKKGNFGDFKSIGDGICELRFTIGPGYRVYYTQKGDEIIILLVGGDKS
TQSKDIEKAKELLKEFDNE

Nucleotide

• Length: 300 bp

>T170733 NZ_CP077693:c1111420-1110893 [Salmonella enterica subsp. enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10087.61 Da
• Isoelectric Point: 4.7719

>AT170733 WP_187474767.1 NZ_CP060693:386211-386489 [Aliarcobacter cryaerophilus]
MSKLATFDISQYLDNKEMIAEYLSQVIEDGDMDELLEAIGNIAKAKGISQIAADTGLGRESLYKTFQSGSKPRFETVMKV
LRSLGVNIKAIA

Nucleotide

• Length: 279 bp

>AT170733 NZ_CP077693:c1111707-1111417 [Salmonella enterica subsp. enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA