Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 79059..80682 Replicon plasmid unnamed
Accession NZ_CP060679
Organism Salmonella enterica strain 190610_1

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag H9Q82_RS23265 Protein ID WP_000088046.1
Coordinates 79059..80384 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag H9Q82_RS23270 Protein ID WP_024136327.1
Coordinates 80389..80682 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q82_RS23235 (H9Q82_23110) 75729..76028 - 300 WP_001572440.1 hypothetical protein -
H9Q82_RS23240 (H9Q82_23115) 76083..76319 - 237 Protein_98 type I restriction-modification system subunit M N-terminal domain-containing protein -
H9Q82_RS23245 (H9Q82_23120) 76773..77198 - 426 WP_001043843.1 hypothetical protein -
H9Q82_RS23250 (H9Q82_23125) 77452..78267 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
H9Q82_RS23255 (H9Q82_23130) 78280..78690 - 411 WP_000985911.1 hypothetical protein -
H9Q82_RS23260 (H9Q82_23135) 78792..78998 - 207 WP_000134171.1 hypothetical protein -
H9Q82_RS23265 (H9Q82_23140) 79059..80384 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
H9Q82_RS23270 (H9Q82_23145) 80389..80682 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
H9Q82_RS23275 (H9Q82_23150) 81314..81706 - 393 WP_000341066.1 hypothetical protein -
H9Q82_RS23280 (H9Q82_23155) 82079..82420 + 342 WP_001151575.1 hypothetical protein -
H9Q82_RS23285 (H9Q82_23160) 82512..82703 + 192 WP_000398480.1 hypothetical protein -
H9Q82_RS23290 (H9Q82_23165) 82753..83034 + 282 WP_000077926.1 hypothetical protein -
H9Q82_RS23295 (H9Q82_23170) 83189..83893 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
H9Q82_RS23300 (H9Q82_23175) 83947..84174 - 228 Protein_110 IS4 family transposase -
H9Q82_RS23305 (H9Q82_23180) 84317..85177 + 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / blaCTX-M-15 / aac(3)-IId pefB / pefA / pefC / pefD / rck / spvB / spvC / fdeC 1..110273 110273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T170731 WP_000088046.1 NZ_CP060679:c80384-79059 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T170731 NZ_CP077693:311935-312303 [Salmonella enterica subsp. enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT170731 WP_024136327.1 NZ_CP060679:c80682-80389 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT170731 NZ_CP077693:311717-311938 [Salmonella enterica subsp. enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References