170727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4048313..4048973 Replicon chromosome
Accession NZ_CP060678
Organism Salmonella enterica strain 190610_1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q82_RS19670 Protein ID WP_000244756.1
Coordinates 4048313..4048726 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q82_RS19675 Protein ID WP_000351186.1
Coordinates 4048707..4048973 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q82_RS19650 (4044254) 4044254..4045987 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
H9Q82_RS19655 (4045993) 4045993..4046706 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q82_RS19660 (4046730) 4046730..4047626 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q82_RS19665 (4047739) 4047739..4048260 + 522 WP_001055885.1 flavodoxin FldB -
H9Q82_RS19670 (4048313) 4048313..4048726 - 414 WP_000244756.1 protein YgfX Toxin
H9Q82_RS19675 (4048707) 4048707..4048973 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q82_RS19680 (4049223) 4049223..4050203 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q82_RS19685 (4050319) 4050319..4050978 - 660 WP_000250289.1 hemolysin III family protein -
H9Q82_RS19690 (4051142) 4051142..4051453 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q82_RS19695 (4051611) 4051611..4053044 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170727 WP_000244756.1 NZ_CP060678:c4048726-4048313 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170727 NZ_CP077691:c4340388-4340104 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170727 WP_000351186.1 NZ_CP060678:c4048973-4048707 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170727 NZ_CP077691:c4340620-4340378 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References