170707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 692990..693771 Replicon chromosome
Accession NZ_CP060678
Organism Salmonella enterica strain 190610_1

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q82_RS03175 Protein ID WP_000626100.1
Coordinates 693280..693771 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q82_RS03170 Protein ID WP_001110452.1
Coordinates 692990..693283 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q82_RS03135 (689037) 689037..689942 + 906 WP_001268200.1 YjiK family protein -
H9Q82_RS03140 (690236) 690236..690367 - 132 Protein_598 hypothetical protein -
H9Q82_RS03145 (690479) 690479..690727 - 249 Protein_599 Ig-like domain-containing protein -
H9Q82_RS03150 (690726) 690726..691034 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q82_RS03155 (691027) 691027..691314 - 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q82_RS03160 (691311) 691311..692186 - 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q82_RS03165 (692452) 692452..692673 - 222 WP_001576552.1 hypothetical protein -
H9Q82_RS03170 (692990) 692990..693283 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q82_RS03175 (693280) 693280..693771 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q82_RS03180 (694019) 694019..694771 - 753 WP_000842433.1 non-specific acid phosphatase -
H9Q82_RS03185 (694871) 694871..694948 - 78 Protein_607 porin family protein -
H9Q82_RS03190 (695328) 695328..695402 + 75 Protein_608 helix-turn-helix domain-containing protein -
H9Q82_RS03200 (695673) 695673..696248 - 576 WP_001188509.1 transcriptional regulator -
H9Q82_RS03205 (696285) 696285..697988 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q82_RS03210 (697964) 697964..698311 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170707 WP_000626100.1 NZ_CP060678:693280-693771 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170707 NZ_CP077680:c2788221-2788118 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170707 WP_001110452.1 NZ_CP060678:692990-693283 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170707 NZ_CP077680:2788116-2788259 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References