Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3755745..3756405 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q83_RS18535 Protein ID WP_000244756.1
Coordinates 3755992..3756405 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q83_RS18530 Protein ID WP_000351186.1
Coordinates 3755745..3756011 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS18510 (3751674) 3751674..3753107 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
H9Q83_RS18515 (3753265) 3753265..3753576 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q83_RS18520 (3753740) 3753740..3754399 + 660 WP_000250289.1 hemolysin III family protein -
H9Q83_RS18525 (3754515) 3754515..3755495 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q83_RS18530 (3755745) 3755745..3756011 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q83_RS18535 (3755992) 3755992..3756405 + 414 WP_000244756.1 protein YgfX Toxin
H9Q83_RS18540 (3756458) 3756458..3756979 - 522 WP_001055885.1 flavodoxin FldB -
H9Q83_RS18545 (3757092) 3757092..3757988 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q83_RS18550 (3758012) 3758012..3758725 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q83_RS18555 (3758731) 3758731..3760464 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170700 WP_000244756.1 NZ_CP060676:3755992-3756405 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170700 NZ_CP077680:c238165-237854 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170700 WP_000351186.1 NZ_CP060676:3755745-3756011 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170700 NZ_CP077680:c237857-237411 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References