Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2847859..2848619 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q83_RS14170 Protein ID WP_000533912.1
Coordinates 2847859..2848344 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q83_RS14175 Protein ID WP_000965886.1
Coordinates 2848332..2848619 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS14140 (2842931) 2842931..2843593 + 663 WP_000747548.1 OmpA family lipoprotein -
H9Q83_RS14145 (2843812) 2843812..2844786 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q83_RS14150 (2844836) 2844836..2845546 - 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q83_RS14155 (2845985) 2845985..2846275 + 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q83_RS14160 (2846563) 2846563..2846775 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q83_RS14165 (2846949) 2846949..2847488 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q83_RS14170 (2847859) 2847859..2848344 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q83_RS14175 (2848332) 2848332..2848619 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q83_RS14180 (2848797) 2848797..2849264 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q83_RS14185 (2849436) 2849436..2849834 - 399 Protein_2773 IS3 family transposase -
H9Q83_RS14190 (2850224) 2850224..2852293 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q83_RS14195 (2852303) 2852303..2853214 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170697 WP_000533912.1 NZ_CP060676:c2848344-2847859 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170697 NZ_CP077679:c251461-251171 [Stenotrophomonas maltophilia]
ATGGCGACCCTCCAGGCAACAGAGACGTTCACGCGCTGGCTGCGCGGGCTCAACGACAGCGGCGCCCGAGCAGTGATCGT
GGAACGCCTGCAGCGGGTCTCCCGCGGTCTCGAGGGAGATGTTCGATCAGTGGGTCATGGCGTGAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACACGTCGCGGAAGATCCATCGTCGTACTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGATCTGCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170697 WP_000965886.1 NZ_CP060676:c2848619-2848332 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170697 NZ_CP077679:c251132-250824 [Stenotrophomonas maltophilia]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCAGACTATCTGGATGATGACGTCGCAATCGCCACCTATCTGAGCGA
GGCCTTGGCAGCAGGTGATGCGGGCCACTTCCAGGAGGCGCTCGGAACTGTTGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCTGGTCTTGGACGCGAGAGCCTGTACAAGGCGCTGCGTCCCGGAGCACACCCGCGCTTCGATACCGTGCAG
CGGGTACTGTCAGCGCTCGGGGTGCATCTCATCGTGCAAGCCGACAAGCAACCCGCTGGCACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References