Detailed information of TA system TA170696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2737904..2738490
• Replicon: chromosome
• Accession: NZ_CP060676
• Organism: Salmonella enterica strain 190704_2

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: H9Q83_RS13685
• Protein ID: WP_000174964.1
• Coordinates: 2737904..2738272 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: H9Q83_RS13690
• Protein ID: WP_001522145.1
• Coordinates: 2738269..2738490 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q83_RS13665 (2733423)	2733423..2734493	-	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
H9Q83_RS13670 (2734495)	2734495..2735340	-	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
H9Q83_RS13675 (2735337)	2735337..2736224	-	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
H9Q83_RS13680 (2736329)	2736329..2737645	-	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
H9Q83_RS13685 (2737904)	2737904..2738272	-	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
H9Q83_RS13690 (2738269)	2738269..2738490	-	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9Q83_RS13695 (2738621)	2738621..2739334	-	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
H9Q83_RS13700 (2739336)	2739336..2740103	-	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
H9Q83_RS13705 (2740100)	2740100..2741377	-	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
H9Q83_RS13710 (2741374)	2741374..2742300	-	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
H9Q83_RS13715 (2742360)	2742360..2743469	-	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2732686..2748710	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T170696 WP_000174964.1 NZ_CP060676:c2738272-2737904 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T170696 NZ_CP077679:c251132-250824 [Stenotrophomonas maltophilia]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCAGACTATCTGGATGATGACGTCGCAATCGCCACCTATCTGAGCGA
GGCCTTGGCAGCAGGTGATGCGGGCCACTTCCAGGAGGCGCTCGGAACTGTTGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCTGGTCTTGGACGCGAGAGCCTGTACAAGGCGCTGCGTCCCGGAGCACACCCGCGCTTCGATACCGTGCAG
CGGGTACTGTCAGCGCTCGGGGTGCATCTCATCGTGCAAGCCGACAAGCAACCCGCTGGCACCGCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT170696 WP_001522145.1 NZ_CP060676:c2738490-2738269 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT170696 NZ_CP077679:c251461-251171 [Stenotrophomonas maltophilia]
ATGGCGACCCTCCAGGCAACAGAGACGTTCACGCGCTGGCTGCGCGGGCTCAACGACAGCGGCGCCCGAGCAGTGATCGT
GGAACGCCTGCAGCGGGTCTCCCGCGGTCTCGAGGGAGATGTTCGATCAGTGGGTCATGGCGTGAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACACGTCGCGGAAGATCCATCGTCGTACTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGATCTGCTGTAG

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4