Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2429462..2430243 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q83_RS12275 Protein ID WP_000626100.1
Coordinates 2429462..2429953 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q83_RS12280 Protein ID WP_001110452.1
Coordinates 2429950..2430243 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS12235 (2424922) 2424922..2425269 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
H9Q83_RS12240 (2425245) 2425245..2426948 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q83_RS12245 (2426985) 2426985..2427560 + 576 WP_001188509.1 transcriptional regulator -
H9Q83_RS12255 (2427831) 2427831..2427905 - 75 Protein_2394 helix-turn-helix domain-containing protein -
H9Q83_RS12260 (2427920) 2427920..2428063 - 144 WP_001125101.1 hypothetical protein -
H9Q83_RS12265 (2428285) 2428285..2428362 + 78 Protein_2396 porin family protein -
H9Q83_RS12270 (2428462) 2428462..2429214 + 753 WP_000842433.1 non-specific acid phosphatase -
H9Q83_RS12275 (2429462) 2429462..2429953 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q83_RS12280 (2429950) 2429950..2430243 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q83_RS12285 (2430560) 2430560..2430781 + 222 WP_001576552.1 hypothetical protein -
H9Q83_RS12290 (2431047) 2431047..2431922 + 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q83_RS12295 (2431919) 2431919..2432206 + 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q83_RS12300 (2432199) 2432199..2432507 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q83_RS12305 (2432506) 2432506..2432754 + 249 Protein_2404 Ig-like domain-containing protein -
H9Q83_RS12310 (2432866) 2432866..2432997 + 132 Protein_2405 hypothetical protein -
H9Q83_RS12315 (2433291) 2433291..2434196 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170694 WP_000626100.1 NZ_CP060676:c2429953-2429462 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170694 NZ_CP077678:c6019912-6019619 [Pseudomonas chlororaphis]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGAGATGACGGCGCGGGTGCATGGGGCGTCTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170694 WP_001110452.1 NZ_CP060676:c2430243-2429950 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170694 NZ_CP077678:c6020208-6019909 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGATCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGAATTCCAGAGCCAGGGCGTTGATCGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGTGACGTGTCCCCGGTGGGCGAAGACGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCTTGGTTCGCAACTCGTCATCCTGTTATGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References