Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2322566..2323082 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag H9Q83_RS11695 Protein ID WP_000220582.1
Coordinates 2322566..2322850 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag H9Q83_RS11700 Protein ID WP_000212724.1
Coordinates 2322840..2323082 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS11680 (2317777) 2317777..2319429 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
H9Q83_RS11685 (2319838) 2319838..2321976 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
H9Q83_RS11690 (2322098) 2322098..2322562 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H9Q83_RS11695 (2322566) 2322566..2322850 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9Q83_RS11700 (2322840) 2322840..2323082 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9Q83_RS11705 (2323160) 2323160..2325073 - 1914 WP_001212142.1 BglG family transcription antiterminator -
H9Q83_RS11710 (2325090) 2325090..2325830 - 741 WP_000779259.1 KDGP aldolase family protein -
H9Q83_RS11715 (2325827) 2325827..2326945 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
H9Q83_RS11720 (2326929) 2326929..2328062 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T170693 WP_000220582.1 NZ_CP060676:c2322850-2322566 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T170693 NZ_CP077678:c4155075-4154794 [Pseudomonas chlororaphis]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAGGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACGGCGGGCTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCCGTGGGCAAG
CGAGAGAGGGGGAGTGTTTATCAGCAAGCCAGCAAGCGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT170693 WP_000212724.1 NZ_CP060676:c2323082-2322840 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT170693 NZ_CP077678:c4155313-4155065 [Pseudomonas chlororaphis]
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATCCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGTCTGGAAGATATGGAGCTGCTCGCCTTGTGCCGTGAACGAAAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References