Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2281441..2281991 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q83_RS11485 Protein ID WP_001199743.1
Coordinates 2281441..2281749 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q83_RS11490 Protein ID WP_001118105.1
Coordinates 2281752..2281991 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS11465 (2278015) 2278015..2278755 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
H9Q83_RS11470 (2278877) 2278877..2279407 - 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q83_RS11475 (2279730) 2279730..2280863 + 1134 Protein_2243 IS3 family transposase -
H9Q83_RS11480 (2280895) 2280895..2281035 - 141 Protein_2244 Arm DNA-binding domain-containing protein -
H9Q83_RS11485 (2281441) 2281441..2281749 - 309 WP_001199743.1 CcdB family protein Toxin
H9Q83_RS11490 (2281752) 2281752..2281991 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q83_RS11495 (2282100) 2282100..2282348 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q83_RS11500 (2282539) 2282539..2282970 - 432 Protein_2248 helix-turn-helix domain-containing protein -
H9Q83_RS11510 (2283727) 2283727..2284746 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q83_RS11515 (2284774) 2284774..2285304 - 531 WP_000896758.1 gluconokinase -
H9Q83_RS11520 (2285521) 2285521..2286552 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2279822..2282925 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170692 WP_001199743.1 NZ_CP060676:c2281749-2281441 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170692 NZ_CP077678:c2380955-2380662 [Pseudomonas chlororaphis]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAACACAGGCGCCGGCTACCGCCTCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170692 WP_001118105.1 NZ_CP060676:c2281991-2281752 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170692 NZ_CP077678:c2380660-2380370 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGCCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACCGTGTCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References