Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2237180..2237756 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag H9Q83_RS11275 Protein ID WP_001131963.1
Coordinates 2237469..2237756 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag H9Q83_RS11270 Protein ID WP_000063142.1
Coordinates 2237180..2237482 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS11255 (2233690) 2233690..2235840 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
H9Q83_RS11260 (2235935) 2235935..2236138 + 204 WP_000460616.1 YbdD/YjiX family protein -
H9Q83_RS11265 (2236149) 2236149..2237105 + 957 WP_000187843.1 GTPase -
H9Q83_RS11270 (2237180) 2237180..2237482 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
H9Q83_RS11275 (2237469) 2237469..2237756 - 288 WP_001131963.1 BrnT family toxin Toxin
H9Q83_RS11280 (2238173) 2238173..2239429 + 1257 Protein_2204 NERD domain-containing protein/DEAD/DEAH box helicase -
H9Q83_RS11285 (2239423) 2239423..2239602 + 180 Protein_2205 DNA methyltransferase -
H9Q83_RS11290 (2239592) 2239592..2240896 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T170691 WP_001131963.1 NZ_CP060676:c2237756-2237469 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T170691 NZ_CP077678:c2380660-2380370 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGCCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACCGTGTCCCGAGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT170691 WP_000063142.1 NZ_CP060676:c2237482-2237180 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT170691 NZ_CP077678:c2380955-2380662 [Pseudomonas chlororaphis]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAACACAGGCGCCGGCTACCGCCTCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References