Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1661689..1662309 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag H9Q83_RS08630 Protein ID WP_001280991.1
Coordinates 1662091..1662309 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag H9Q83_RS08625 Protein ID WP_000344807.1
Coordinates 1661689..1662063 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS08615 (1656828) 1656828..1658021 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9Q83_RS08620 (1658044) 1658044..1661193 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
H9Q83_RS08625 (1661689) 1661689..1662063 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
H9Q83_RS08630 (1662091) 1662091..1662309 + 219 WP_001280991.1 HHA domain-containing protein Toxin
H9Q83_RS08635 (1662488) 1662488..1663039 + 552 WP_001278793.1 maltose O-acetyltransferase -
H9Q83_RS08640 (1663157) 1663157..1663627 + 471 WP_000136183.1 YlaC family protein -
H9Q83_RS08645 (1663683) 1663683..1663823 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
H9Q83_RS08650 (1663829) 1663829..1664089 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
H9Q83_RS08655 (1664314) 1664314..1665864 + 1551 WP_000213140.1 EAL domain-containing protein -
H9Q83_RS08665 (1666095) 1666095..1666484 + 390 WP_000961287.1 MGMT family protein -
H9Q83_RS08670 (1666517) 1666517..1667086 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T170687 WP_001280991.1 NZ_CP060676:1662091-1662309 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T170687 NZ_CP077678:316231-316413 [Pseudomonas chlororaphis]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAATA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT170687 WP_000344807.1 NZ_CP060676:1661689-1662063 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT170687 NZ_CP077678:316443-316844 [Pseudomonas chlororaphis]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGGGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGTTTTCTCGCGGCAGCGGCATTGCGCGAGTTGTCGGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References