Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3435895..3436555 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q84_RS16795 Protein ID WP_000244756.1
Coordinates 3435895..3436308 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q84_RS16800 Protein ID WP_000351186.1
Coordinates 3436289..3436555 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS16775 (3431836) 3431836..3433569 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
H9Q84_RS16780 (3433575) 3433575..3434288 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q84_RS16785 (3434312) 3434312..3435208 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q84_RS16790 (3435321) 3435321..3435842 + 522 WP_001055885.1 flavodoxin FldB -
H9Q84_RS16795 (3435895) 3435895..3436308 - 414 WP_000244756.1 protein YgfX Toxin
H9Q84_RS16800 (3436289) 3436289..3436555 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q84_RS16805 (3436805) 3436805..3437785 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q84_RS16810 (3437901) 3437901..3438560 - 660 WP_000250289.1 hemolysin III family protein -
H9Q84_RS16815 (3438724) 3438724..3439035 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q84_RS16820 (3439193) 3439193..3440626 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170669 WP_000244756.1 NZ_CP060674:c3436308-3435895 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170669 NZ_CP077670:c4496769-4496395 [Salmonella enterica]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170669 WP_000351186.1 NZ_CP060674:c3436555-3436289 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170669 NZ_CP077670:c4497011-4496769 [Salmonella enterica]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References