Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 187743..188259 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag H9Q84_RS00870 Protein ID WP_000220582.1
Coordinates 187975..188259 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag H9Q84_RS00865 Protein ID WP_000212724.1
Coordinates 187743..187985 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS00845 (182763) 182763..183896 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
H9Q84_RS00850 (183880) 183880..184998 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
H9Q84_RS00855 (184995) 184995..185735 + 741 WP_000779259.1 KDGP aldolase family protein -
H9Q84_RS00860 (185752) 185752..187665 + 1914 WP_001212142.1 BglG family transcription antiterminator -
H9Q84_RS00865 (187743) 187743..187985 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9Q84_RS00870 (187975) 187975..188259 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9Q84_RS00875 (188263) 188263..188727 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H9Q84_RS00880 (188849) 188849..190987 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
H9Q84_RS00885 (191396) 191396..193048 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T170650 WP_000220582.1 NZ_CP060674:187975-188259 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T170650 NZ_CP077668:2146771-2146874 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT170650 WP_000212724.1 NZ_CP060674:187743-187985 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT170650 NZ_CP077668:c2146876-2146731 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8


Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References