Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 44591..46214 | Replicon | plasmid unnamed |
Accession | NZ_CP060673 | ||
Organism | Salmonella enterica strain 190729_8 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | H9TH67 |
Locus tag | H9Q85_RS23065 | Protein ID | WP_000088046.1 |
Coordinates | 44889..46214 (+) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
Locus tag | H9Q85_RS23060 | Protein ID | WP_024136327.1 |
Coordinates | 44591..44884 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H9Q85_RS23025 (H9Q85_22880) | 40096..40956 | - | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
H9Q85_RS23030 (H9Q85_22885) | 41099..41326 | + | 228 | Protein_54 | IS4 family transposase | - |
H9Q85_RS23035 (H9Q85_22890) | 41380..42084 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
H9Q85_RS23040 (H9Q85_22895) | 42239..42520 | - | 282 | WP_000077926.1 | hypothetical protein | - |
H9Q85_RS23045 (H9Q85_22900) | 42570..42761 | - | 192 | WP_000398480.1 | hypothetical protein | - |
H9Q85_RS23050 (H9Q85_22905) | 42853..43194 | - | 342 | WP_001151575.1 | hypothetical protein | - |
H9Q85_RS23055 (H9Q85_22910) | 43567..43959 | + | 393 | WP_000341066.1 | hypothetical protein | - |
H9Q85_RS23060 (H9Q85_22915) | 44591..44884 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
H9Q85_RS23065 (H9Q85_22920) | 44889..46214 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
H9Q85_RS23070 (H9Q85_22925) | 46275..46481 | + | 207 | WP_000134171.1 | hypothetical protein | - |
H9Q85_RS23075 (H9Q85_22930) | 46583..46993 | + | 411 | WP_000985911.1 | hypothetical protein | - |
H9Q85_RS23080 (H9Q85_22935) | 47006..47821 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
H9Q85_RS23085 (H9Q85_22940) | 48075..48500 | + | 426 | WP_001043843.1 | hypothetical protein | - |
H9Q85_RS23090 (H9Q85_22945) | 48954..49190 | + | 237 | Protein_66 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
H9Q85_RS23095 (H9Q85_22950) | 49245..49544 | + | 300 | WP_001572440.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(3)-IId / blaCTX-M-15 / tet(A) | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..110273 | 110273 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T170648 WP_000088046.1 NZ_CP060673:44889-46214 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T170648 NZ_CP077668:882568-882966 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT170648 WP_024136327.1 NZ_CP060673:44591-44884 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT170648 NZ_CP077668:882341-882568 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0VBU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Z6V2D1 |