Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 44591..46214 Replicon plasmid unnamed
Accession NZ_CP060673
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag H9Q85_RS23065 Protein ID WP_000088046.1
Coordinates 44889..46214 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag H9Q85_RS23060 Protein ID WP_024136327.1
Coordinates 44591..44884 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS23025 (H9Q85_22880) 40096..40956 - 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -
H9Q85_RS23030 (H9Q85_22885) 41099..41326 + 228 Protein_54 IS4 family transposase -
H9Q85_RS23035 (H9Q85_22890) 41380..42084 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
H9Q85_RS23040 (H9Q85_22895) 42239..42520 - 282 WP_000077926.1 hypothetical protein -
H9Q85_RS23045 (H9Q85_22900) 42570..42761 - 192 WP_000398480.1 hypothetical protein -
H9Q85_RS23050 (H9Q85_22905) 42853..43194 - 342 WP_001151575.1 hypothetical protein -
H9Q85_RS23055 (H9Q85_22910) 43567..43959 + 393 WP_000341066.1 hypothetical protein -
H9Q85_RS23060 (H9Q85_22915) 44591..44884 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
H9Q85_RS23065 (H9Q85_22920) 44889..46214 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
H9Q85_RS23070 (H9Q85_22925) 46275..46481 + 207 WP_000134171.1 hypothetical protein -
H9Q85_RS23075 (H9Q85_22930) 46583..46993 + 411 WP_000985911.1 hypothetical protein -
H9Q85_RS23080 (H9Q85_22935) 47006..47821 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
H9Q85_RS23085 (H9Q85_22940) 48075..48500 + 426 WP_001043843.1 hypothetical protein -
H9Q85_RS23090 (H9Q85_22945) 48954..49190 + 237 Protein_66 type I restriction-modification system subunit M N-terminal domain-containing protein -
H9Q85_RS23095 (H9Q85_22950) 49245..49544 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / blaCTX-M-15 / tet(A) rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB 1..110273 110273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T170648 WP_000088046.1 NZ_CP060673:44889-46214 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T170648 NZ_CP077668:882568-882966 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT170648 WP_024136327.1 NZ_CP060673:44591-44884 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT170648 NZ_CP077668:882341-882568 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References