Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4675276..4676036 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q85_RS22725 Protein ID WP_000533912.1
Coordinates 4675276..4675761 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q85_RS22730 Protein ID WP_000965886.1
Coordinates 4675749..4676036 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS22695 (4670348) 4670348..4671010 + 663 WP_000747548.1 OmpA family lipoprotein -
H9Q85_RS22700 (4671229) 4671229..4672203 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q85_RS22705 (4672253) 4672253..4672963 - 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q85_RS22710 (4673402) 4673402..4673692 + 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q85_RS22715 (4673980) 4673980..4674192 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q85_RS22720 (4674366) 4674366..4674905 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q85_RS22725 (4675276) 4675276..4675761 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q85_RS22730 (4675749) 4675749..4676036 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q85_RS22735 (4676214) 4676214..4676681 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q85_RS22740 (4676853) 4676853..4677251 - 399 Protein_4426 IS3 family transposase -
H9Q85_RS22745 (4677641) 4677641..4679710 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q85_RS22750 (4679720) 4679720..4680631 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170646 WP_000533912.1 NZ_CP060672:c4675761-4675276 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170646 NZ_CP077668:365574-365849 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170646 WP_000965886.1 NZ_CP060672:c4676036-4675749 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170646 NZ_CP077668:365311-365571 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References