Detailed information of TA system TA170645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4565321..4565907
• Replicon: chromosome
• Accession: NZ_CP060672
• Organism: Salmonella enterica strain 190729_8

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: H9Q85_RS22240
• Protein ID: WP_000174964.1
• Coordinates: 4565321..4565689 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: H9Q85_RS22245
• Protein ID: WP_001522145.1
• Coordinates: 4565686..4565907 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q85_RS22220 (4560840)	4560840..4561910	-	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
H9Q85_RS22225 (4561912)	4561912..4562757	-	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
H9Q85_RS22230 (4562754)	4562754..4563641	-	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
H9Q85_RS22235 (4563746)	4563746..4565062	-	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
H9Q85_RS22240 (4565321)	4565321..4565689	-	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
H9Q85_RS22245 (4565686)	4565686..4565907	-	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9Q85_RS22250 (4566038)	4566038..4566751	-	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
H9Q85_RS22255 (4566753)	4566753..4567520	-	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
H9Q85_RS22260 (4567517)	4567517..4568794	-	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
H9Q85_RS22265 (4568791)	4568791..4569717	-	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
H9Q85_RS22270 (4569777)	4569777..4570886	-	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4560103..4576127	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T170645 WP_000174964.1 NZ_CP060672:c4565689-4565321 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T170645 NZ_CP077668:317436-317804 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT170645 WP_001522145.1 NZ_CP060672:c4565907-4565686 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT170645 NZ_CP077668:317218-317439 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4