Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4049737..4050397 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q85_RS19685 Protein ID WP_000244756.1
Coordinates 4049737..4050150 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q85_RS19690 Protein ID WP_000351186.1
Coordinates 4050131..4050397 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS19665 (4045678) 4045678..4047411 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
H9Q85_RS19670 (4047417) 4047417..4048130 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q85_RS19675 (4048154) 4048154..4049050 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q85_RS19680 (4049163) 4049163..4049684 + 522 WP_001055885.1 flavodoxin FldB -
H9Q85_RS19685 (4049737) 4049737..4050150 - 414 WP_000244756.1 protein YgfX Toxin
H9Q85_RS19690 (4050131) 4050131..4050397 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q85_RS19695 (4050647) 4050647..4051627 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q85_RS19700 (4051743) 4051743..4052402 - 660 WP_000250289.1 hemolysin III family protein -
H9Q85_RS19705 (4052566) 4052566..4052877 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q85_RS19710 (4053035) 4053035..4054468 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170643 WP_000244756.1 NZ_CP060672:c4050150-4049737 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170643 NZ_CP077663:2756-3004 [Salmonella enterica]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170643 WP_000351186.1 NZ_CP060672:c4050397-4050131 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170643 NZ_CP077663:3001-3348 [Salmonella enterica]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References