170630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1462347..1462967 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag H9Q85_RS06840 Protein ID WP_001280991.1
Coordinates 1462347..1462565 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag H9Q85_RS06845 Protein ID WP_000344807.1
Coordinates 1462593..1462967 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS06800 (1457570) 1457570..1458139 + 570 WP_000779802.1 YbaY family lipoprotein -
H9Q85_RS06805 (1458172) 1458172..1458561 - 390 WP_000961287.1 MGMT family protein -
H9Q85_RS06815 (1458792) 1458792..1460342 - 1551 WP_000213140.1 EAL domain-containing protein -
H9Q85_RS06820 (1460567) 1460567..1460827 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
H9Q85_RS06825 (1460833) 1460833..1460973 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
H9Q85_RS06830 (1461029) 1461029..1461499 - 471 WP_000136183.1 YlaC family protein -
H9Q85_RS06835 (1461617) 1461617..1462168 - 552 WP_001278793.1 maltose O-acetyltransferase -
H9Q85_RS06840 (1462347) 1462347..1462565 - 219 WP_001280991.1 HHA domain-containing protein Toxin
H9Q85_RS06845 (1462593) 1462593..1462967 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
H9Q85_RS06850 (1463463) 1463463..1466612 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
H9Q85_RS06855 (1466635) 1466635..1467828 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T170630 WP_001280991.1 NZ_CP060672:c1462565-1462347 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T170630 NZ_CP077662:351474-351749 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATTACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT170630 WP_000344807.1 NZ_CP060672:c1462967-1462593 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT170630 NZ_CP077662:351211-351471 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References