Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 886906..887482 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag H9Q85_RS04185 Protein ID WP_001131963.1
Coordinates 886906..887193 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag H9Q85_RS04190 Protein ID WP_000063142.1
Coordinates 887180..887482 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS04170 (883766) 883766..885070 - 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -
H9Q85_RS04175 (885060) 885060..885239 - 180 Protein_800 DNA methyltransferase -
H9Q85_RS04180 (885233) 885233..886489 - 1257 Protein_801 NERD domain-containing protein/DEAD/DEAH box helicase -
H9Q85_RS04185 (886906) 886906..887193 + 288 WP_001131963.1 BrnT family toxin Toxin
H9Q85_RS04190 (887180) 887180..887482 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
H9Q85_RS04195 (887557) 887557..888513 - 957 WP_000187843.1 GTPase -
H9Q85_RS04200 (888524) 888524..888727 - 204 WP_000460616.1 YbdD/YjiX family protein -
H9Q85_RS04205 (888822) 888822..890972 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T170626 WP_001131963.1 NZ_CP060672:886906-887193 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T170626 NZ_CP077661:2001067-2001408 [Enterobacter cloacae complex sp. ECL112]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT170626 WP_000063142.1 NZ_CP060672:887180-887482 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT170626 NZ_CP077661:2000729-2001046 [Enterobacter cloacae complex sp. ECL112]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References