Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 842671..843221 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q85_RS03975 Protein ID WP_001199743.1
Coordinates 842913..843221 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q85_RS03970 Protein ID WP_001118105.1
Coordinates 842671..842910 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS03935 (838110) 838110..839141 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
H9Q85_RS03940 (839358) 839358..839888 + 531 WP_000896758.1 gluconokinase -
H9Q85_RS03945 (839916) 839916..840935 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q85_RS03955 (841692) 841692..842123 + 432 Protein_756 helix-turn-helix domain-containing protein -
H9Q85_RS03960 (842154) 842154..842237 + 84 WP_228958541.1 DUF4942 domain-containing protein -
H9Q85_RS03965 (842314) 842314..842562 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q85_RS03970 (842671) 842671..842910 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q85_RS03975 (842913) 842913..843221 + 309 WP_001199743.1 CcdB family protein Toxin
H9Q85_RS03980 (843627) 843627..843767 + 141 Protein_761 Arm DNA-binding domain-containing protein -
H9Q85_RS03985 (843799) 843799..844932 - 1134 Protein_762 IS3 family transposase -
H9Q85_RS03990 (845255) 845255..845785 + 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q85_RS03995 (845907) 845907..846647 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 841737..844840 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170625 WP_001199743.1 NZ_CP060672:842913-843221 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170625 NZ_CP077661:1539498-1539683 [Enterobacter cloacae complex sp. ECL112]
GTGAAAAGTGCGGATATCATTACTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTTACCGTCCCACATCCTAAAAAGGACATTAAACCAGGCACTCTCGCACAAATCT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170625 WP_001118105.1 NZ_CP060672:842671-842910 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170625 NZ_CP077661:1539698-1540105 [Enterobacter cloacae complex sp. ECL112]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGATGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCACTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAGAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References