Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 801580..802096 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag H9Q85_RS03760 Protein ID WP_000220582.1
Coordinates 801812..802096 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag H9Q85_RS03755 Protein ID WP_000212724.1
Coordinates 801580..801822 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS03735 (796600) 796600..797733 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
H9Q85_RS03740 (797717) 797717..798835 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
H9Q85_RS03745 (798832) 798832..799572 + 741 WP_000779259.1 KDGP aldolase family protein -
H9Q85_RS03750 (799589) 799589..801502 + 1914 WP_001212142.1 BglG family transcription antiterminator -
H9Q85_RS03755 (801580) 801580..801822 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9Q85_RS03760 (801812) 801812..802096 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9Q85_RS03765 (802100) 802100..802564 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H9Q85_RS03770 (802686) 802686..804824 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
H9Q85_RS03775 (805233) 805233..806885 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T170624 WP_000220582.1 NZ_CP060672:801812-802096 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T170624 NZ_CP077661:1030851-1031138 [Enterobacter cloacae complex sp. ECL112]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT170624 WP_000212724.1 NZ_CP060672:801580-801822 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT170624 NZ_CP077661:1030542-1030844 [Enterobacter cloacae complex sp. ECL112]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References